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Evaluation of some pharmacological activities of Budmunchiamine - A isolated from Albizia amara
Thippeswamy, Sreerangegowda; Mohana, Devihalli Chikkaiah; Abhishek, Rayasandra Umesh; Manjunath, Kiragandur.
Afiliação
  • Thippeswamy, Sreerangegowda; Bangalore University. Department of Microbiology and Biotechnology. Jnanabharathi. IN
  • Mohana, Devihalli Chikkaiah; Bangalore University. Department of Microbiology and Biotechnology. Jnanabharathi. IN
  • Abhishek, Rayasandra Umesh; Bangalore University. Department of Microbiology and Biotechnology. Jnanabharathi. IN
  • Manjunath, Kiragandur; Bangalore University. Department of Microbiology and Biotechnology. Jnanabharathi. IN
Braz. j. microbiol ; 46(1): 139-143, 05/2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-748240
Biblioteca responsável: BR1.1
ABSTRACT
The present investigations were aimed to evaluate the antimicrobial and antioxidant efficacies of budmunchiamine-A (BUA) of Albizia amara. The activity-guided isolation leaded to isolate the bioactive compound budmunchiamine-A from alkaloid extract of A. amara. The budmunchiamine-A showed significant broad-spectrum antimicrobial activity with zone of inhibition (ZOI), minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) values varied from 7.3 to 24.5 mm, 0.95 to 62.5 μg/mL, and 1.9 to 250 μg/mL, respectively. The budmunchiamine-A exhibited moderate antioxidant activity with inhibitory concentration 50% (IC50) value of 400 μg/mL in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and percent inhibition of β-carotene/linoleic acid was 67.8%. The results suggest the possible use of budmunchiamine-A as a molecular entity for drug development in pharmaceutical industry.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Extratos Vegetais / Albizzia / Anti-Infecciosos / Antioxidantes Idioma: Inglês Revista: Braz. j. microbiol Assunto da revista: Microbiologia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Bangalore University/IN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Extratos Vegetais / Albizzia / Anti-Infecciosos / Antioxidantes Idioma: Inglês Revista: Braz. j. microbiol Assunto da revista: Microbiologia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Bangalore University/IN
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