Your browser doesn't support javascript.
loading
Swim training and the genetic expression of adipokines in monosodium glutamate-treated obese rats
Svidnicki, Paulo Vinicius; Leite, Nayara Carvalho; Vicari, Marcelo Ricardo; Almeida, Mara Cristina de; Artoni, Roberto Ferreira; Favero, Giovani Marino; Grassiolli, Sabrina; Nogaroto, Viviane.
Afiliação
  • Svidnicki, Paulo Vinicius; Universidade Estadual de Ponta Grossa. Department of Structural, Molecular and Genetic Biology. Ponta Grossa. BR
  • Leite, Nayara Carvalho; Universidade Estadual de Ponta Grossa. Department of Structural, Molecular and Genetic Biology. Ponta Grossa. BR
  • Vicari, Marcelo Ricardo; Universidade Estadual de Ponta Grossa. Department of Structural, Molecular and Genetic Biology. Ponta Grossa. BR
  • Almeida, Mara Cristina de; Universidade Estadual de Ponta Grossa. Department of Structural, Molecular and Genetic Biology. Ponta Grossa. BR
  • Artoni, Roberto Ferreira; Universidade Estadual de Ponta Grossa. Department of Structural, Molecular and Genetic Biology. Ponta Grossa. BR
  • Favero, Giovani Marino; Universidade Estadual de Ponta Grossa. Department of Structural, Molecular and Genetic Biology. Ponta Grossa. BR
  • Grassiolli, Sabrina; Universidade Estadual de Ponta Grossa. Department of Structural, Molecular and Genetic Biology. Ponta Grossa. BR
  • Nogaroto, Viviane; Universidade Estadual de Ponta Grossa. Department of Structural, Molecular and Genetic Biology. Ponta Grossa. BR
Arch. endocrinol. metab. (Online) ; 59(3): 210-214, 06/2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-751317
Biblioteca responsável: BR1.1
ABSTRACT
Objective The aim of this study was to evaluate the genetic expression of adipokines in the adipocytes of monosodium glutamate (MSG)-treated obese rats submitted to physical activity.Materials and methods Obesity was induced by neonatal MSG administration. Exercised rats (MSG and control) were subjected to swim training for 30 min for 10 weeks, whereas their respective controls remained sedentary. Total RNA was obtained from sections of the mesenteric adipose tissue of the rats. mRNA levels of adiponectin (Adipoq), tumor necrosis factor alpha (Tnf), peroxisome proliferator-activated receptor alpha (Ppara), and peroxisome proliferator-activated receptor gamma (Pparg) adipokines were quantified by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR).Results In the exercise-trained control group, the expression of Adipoq increased compared to the sedentary control, which was not observed in the MSG-obese rats. Increased levels of Tnf in MSG-obese rats were not reversed by the swim training. The expression of Ppara was higher in sedentary MSG-obese rats compared to the sedentary control. Swimming increased this adipokine expression in the exercise-trained control rats compared to the sedentary ones. mRNA levels of Pparg were higher in the sedentary MSG-rats compared to the sedentary control; however, the exercise did not influenced its expression in the groups analyzed.Conclusions In conclusion, regular physical activity was not capable to correct the expression of proinflammatory adipokines in MSG-obese rat adipocytes.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Vacinas / Vacinas Sintéticas / Adjuvantes Imunológicos / Mimetismo Molecular / Fatores de Necrose Tumoral Limite: Animais / Humanos Idioma: Inglês Revista: Arch. endocrinol. metab. (Online) Assunto da revista: Endocrinologia / Metabolismo Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Estadual de Ponta Grossa/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Vacinas / Vacinas Sintéticas / Adjuvantes Imunológicos / Mimetismo Molecular / Fatores de Necrose Tumoral Limite: Animais / Humanos Idioma: Inglês Revista: Arch. endocrinol. metab. (Online) Assunto da revista: Endocrinologia / Metabolismo Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Estadual de Ponta Grossa/BR
...