Your browser doesn't support javascript.
loading
Expression of PECAM-1 and E-Cadherin in the Umblical Cords of Gestational Diabetic Mothers / Expresión de PECAM-1 y E-cadherina en los Cordones Umbilicales de Madres con Diabetes Gestacional
Tahaoglu, A. E; Togrul, C; Külahcioglu, M. I; Bademkiran, M. H; Balsak, D; Mavi gök, E; Ekinci, C; Deveci, E.
Afiliação
  • Tahaoglu, A. E; Diyarbakir Maternity and Children Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
  • Togrul, C; Diyarbakir Maternity and Children Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
  • Külahcioglu, M. I; Diyarbakir Maternity and Children Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
  • Bademkiran, M. H; Diyarbakir Maternity and Children Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
  • Balsak, D; Diyarbakir Maternity and Children Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
  • Mavi gök, E; Diyarbakir Maternity and Children Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
  • Ekinci, C; Diyarbakir Maternity and Children Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
  • Deveci, E; Diyarbakir Maternity and Children Hospital. Department of Obstetrics and Gynecology. Diyarbakir. TR
Int. j. morphol ; 33(4): 1277-1281, Dec. 2015. ilus
Artigo em Inglês | LILACS | ID: lil-772308
Biblioteca responsável: CL1.1
ABSTRACT
The purpose of this study is to examine the changes in the umbilical cord in women diagnosed with gestational diabetes mellitus In this study, as a control group human placental tissues from normotensive pregnancies was collected from diabetic women at 28­35 weeks of gestation. Gestational diabetes (n= 20) and normal umbilical cord (n= 20) for a total of 40 units were received.GDM groups compared to the control group was significantly higher values was detected (p<0.01). In GDM group, light microscopy showed erosion of the endothelium and complete rupture of theumbilicalvessels resulting in extravasation of blood within Wharton's jelly. it was observed that the cytoplasmic fragments and cell infiltration of the spill to the subepithelial layer of apoptotic cell PECAM-1 positive reaction showed. E-Cadherin in endothelial side surface of diabetes group showed weak expression in the nucleus and showed positive reaction in smooth muscle.
RESUMEN
El objetivo fue examinar los cambios que presenta el cordón umbilical de mujeres con diagnóstico de diabetes mellitus gestacional (DMG). Se incluyeron en el grupo control muestras de tejidos placentarios humanos de embarazos normotensos y de mujeres diabéticas de entre 28­35 semanas de gestación. Las muestras se divieron en cordones umbilicales con cambios de DMG (n= 20) y cordones umbilicales normales (n= 20), constituyendo un total de 40 muestras. El grupo de DMG, en comparación con el grupo control, presentó valores significativamente más elevados (p<0,01). En el grupo de DMG, la microscopía óptica demostró la erosión del endotelio y la ruptura completa de los vasos umbilicales, resultando en la extravasación de sangre dentro de la gelatina . Se observaron fragmentos citoplasmáticos e infiltración celular de la capa subepitelial de células apoptóticas mostró una reacción positiva a PECAM-1. En el grupo de DMG, la E-cadherina de la superficie lateral endotelial mostró una expresión débil en el núcleo y una reacción positiva en el músculo liso.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Cordão Umbilical / Caderinas / Diabetes Gestacional / Molécula-1 de Adesão Celular Endotelial a Plaquetas Limite: Feminino / Humanos / Gravidez Idioma: Inglês Revista: Int. j. morphol Assunto da revista: Anatomia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Diyarbakir Maternity and Children Hospital/TR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Cordão Umbilical / Caderinas / Diabetes Gestacional / Molécula-1 de Adesão Celular Endotelial a Plaquetas Limite: Feminino / Humanos / Gravidez Idioma: Inglês Revista: Int. j. morphol Assunto da revista: Anatomia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Diyarbakir Maternity and Children Hospital/TR
...