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Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core.

Bioorg Med Chem Lett; 18(2): 474-8, 2008 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-18160281
T-type calcium channel antagonists were designed using a protocol involving the program SPROUT and constrained by a ComFA-based pharmacophore model. Scaffolds generated by SPROUT were evaluated based on their ability to be translated into structures that were synthetically tractable. From this exercise, a novel series of potent and selective T-type channel antagonists containing a biaryl sulfonamide core were discovered.