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A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis.

J Rheumatol; 38(12): 2598-601, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21965647

OBJECTIVE:

To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA).

METHODS:

A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology.

RESULTS:

No association was observed between ITGAM rs1143679 and GCA (p = 0.80, OR 0.97). Similarly, subphenotype analyses did not yield significant differences between the case subgroups and the control set or between GCA patients with or without the main specific features of GCA.

CONCLUSION:

Our results suggest that the ITGAM rs1143679 variant does not play an important role in the pathophysiology of GCA.