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[An analysis on biomedical effects of bipolar electric pulses at different central frequency].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 29(3): 438-42, 2012 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-22826935
Adopting the cell model of multilayer spherical symmetry and the circuit analysis, the present paper gives the calculated results of the voltages on each of several parts of malignant Tonsillar B-cells and Jurkat T lymphocytes when the first-order Gaussian pulses at different central frequency apposed on them. The relationship between the central frequency and the transmembrane voltages of plasma membrane is also given. The optimum frequency causing electroporation in nuclear envelope is given as well. The paper discusses the reasons of electroporation in membrane and DNA degradation in nuclear. The work provides a reference for usage of transient bipolar electric pulses in cancer treatment.