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TNF-α and LT-α polymorphisms and the risk of leukemia: a meta-analysis.

Tumori; 103(1): 53-59, 2017 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-27647233

AIM:

The aim of this study is to investigate whether TNF-α or LT-α polymorphisms are associated with the risk of leukemia.

METHODS:

A meta-analysis was performed to examine the association between the TNF-α -308 G>A and LT-α +252 A>G polymorphisms and the incidence of leukemia. We also performed subgroup analyses based on the classification of leukemias. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association.

RESULTS:

A total of 19 publications comprising 1,509 cases and 4,075 controls were selected in the study. An association between the risk of leukemia and the LT-α +252 AA genotype was found (GG + AG vs. AA, OR = 0.485, 95% CI 0.368-0.639, p = 0.000). After multivariable analysis TNF-α polymorphism showed no consistent association with leukemia.

CONCLUSIONS:

This meta-analysis suggests that the LT-α +252 AA polymorphism is associated with the risk of leukemia.