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1,5-Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid-(1-40) Fibrillization.

Adv Sci (Weinh); 3(10): 1600082, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-27840798
derived from polyamines and acrolein, inhibit Aß40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases.