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Infection Risk With Biologic Therapy in Patients With Inflammatory Bowel Disease.

Clin Pharmacol Ther; 102(4): 633-641, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28699217
The development of biologic drugs revolutionized the management of inflammatory bowel diseases: Crohn's disease and ulcerative colitis. However, while their efficacy has been well established, it remains uncertain to what extent biologic treatments may be associated with important safety risks, such as serious infections, opportunistic infections, or tuberculosis reactivation. Herein, we review and discuss the current evidence on the infection risk associated with biologic therapy in patients with inflammatory bowel disease (IBD).