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Feasibility, Acceptability And Adherence With Short Term Hiv Pre-Exposure Prophylaxis In Female Sexual Partners Of Migrant Miners In Mozambique.

Artigo em Inglês | MEDLINE | ID: mdl-28777264

Resumo

BACKGROUND: Pre-exposure prophylaxis (PrEP) offers protection from HIV acquisition if taken as prescribed. We evaluated the feasibility, acceptability and adherence with short-term PrEP among female sexual partners of migrant miners in Mozambique. METHODS: HIV-negative female sexual partners of migrant miners were offered daily tenofovir/emtricitabine (TDF/FTC) for 6 weeks concurrent with miners' return home. Study visits occurred at baseline, Week 4, 6 and 8. Dried blood spots (DBS) were collected at Week 4 and 6. RESULTS: Seventy-four women (median age:42 years) were enrolled, 95% reported having one sexual partner and 80% reported never or rarely using condoms. At baseline, 41% had never tested for HIV; 65% were unaware of partners' HIV status. Of all women, 72(97%) initiated PrEP, 7(9%) discontinued PrEP before Week 6; only one due to adverse events. Missed doses in the last week were self-reported by 8% and 3% of women at Week 4 and 6, respectively. Of 66 (89%) women with DBS at Week 4, 79% had detectable tenofovir-diphosphate (TFV-DP) and 44% had levels consistent with ≥4 pills/week (≥700fmol/punch). Of 63 (88%) women with DBS at Week 6, 76% had detectable TFV-DP and 42% had levels consistent with ≥4pills/week. CONCLUSIONS: In this first study assessing use of short-term PrEP, a high percent of female partners of migrant workers initiated PrEP and had detectable TDF-DP levels during follow-up. Further efforts are needed to enhance adherence to ensure protection from HIV acquisition. Short-term PrEP offers promise for populations who are at high-risk for HIV during specific periods of time.This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.