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Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease.

World J Gastroenterol; 23(47): 8300-8307, 2017 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-29307990

AIM:

To investigate whether common variants in the oxidative pathway genes influence inflammatory bowel disease (IBD) risk among Moroccan patients.

METHODS:

The distribution of (TAAA)n_rs12720460 and (CCTTT)n _rs3833912 microsatellite repeats, - _rs11549467 and -94ins/delATTG_rs28362491 was analyzed in 507 subjects grouped in 199 IBD and 308 healthy controls. Genotyping was performed with polymerase chain reaction-fluorescent method and the TaqMan allelic discrimination technology.

RESULTS:

The allele and genotype frequencies of _ rs11549467, _rs28362491 and _ (TAAA)n did not differ significantly between patients and controls. Analysis of _ (CCTTT)n markers evidenced differences between patients and healthy controls. A preferential presence of the (CCTTT)8 ( = 0.02; OR = 1.71, 95%CI: 1.07-2.74), (CCTTT)14 ( = 0.02; OR = 1.71, 95%CI: 1.06-2.76) alleles in IBD, (CCTTT)8 ( = 0.008; OR = 1.95, 95%CI: 1.17-3.23) in CD and (CCTTT)7 ( = 0.009; OR = 7.61, 95%CI: 1.25-46.08), (CCTTT)11 ( = 0.05; OR = 0.51, 95%CI: 0.25-1.01), (CCTTT)14 ( = 0.02; OR = 2.05, 95%CI: 1.07-3.94), (CCTTT)15 ( = 0.01; OR = 2.25, 95%CI: 1.16-4.35) repeats in UC patients indicated its possible association with higher disease risk which need to be confirmed in a larger sample size.

CONCLUSION:

Our results suggest that the _ (CCTTT)n gene variations may influence IBD susceptibility in the Moroccan population.