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Comparison of and polymorphisms in Chinese patients with inflammatory bowel disease.

World J Gastroenterol; 24(8): 941-948, 2018 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-29491687
AIM: To observe gene polymorphisms of and , and compare their predictive value for azathioprine (AZA)-induced leukopenia in inflammatory bowel disease (IBD).


This study enrolled 219 patients diagnosed with IBD in Xiangya Hospital, Central South University, Changsha, China from February 2016 to November 2017. Peripheral blood of all patients was collected to detect their genotypes of and by pyrosequencing at the Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital. Eighty patients were treated with AZA according to the disease condition. During the first month, patients who received AZA underwent routine bl RESULTS: There were 219 patients with IBD (160 men and 59 women), including 39 who were confirmed with ulcerative colitis (UC), 176 with Crohn's disease (CD) and 4 with undetermined IBD (UIBD). There were 44 patients (20.1%) with mutant genotype of (C/T); among them, 16 received AZA, and 8 (50%) developed leukopenia. There were 175 patients (79.7%) with wild genotype of (C/C); among them, 64 received AZA, and 11 (17.2%) developed leukopenia. A significant difference was found between C/T and its wild- CONCLUSION: Mutation rate of in Chinese IBD patients is higher than that of . polymorphism is a better predictor for AZA-induced leukopenia than polymorphism.