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l-Glutamine Attenuates DSS-Induced Colitis via Induction of MAPK Phosphatase-1.

Nutrients; 10(3)2018 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-29494494
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a multifactorial inflammatory disease of the small intestine and colon. Many investigators have reported that l-glutamine (Gln) therapy improves outcomes of experimental colitis models, although the mechanism is not fully understood. Regarding the anti-inflammatory properties of Gln, we have shown that Gln can effectively deactivate cytosolic phospholipase A2 (cPLA2) by rapid induction of MAPK phosphatase (