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Deleted in malignant brain tumor 1 is a novel prognostic marker in colorectal cancer.

Oncol Rep; 39(5): 2279-2287, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29498404
The gene deleted in malignant brain tumor 1 (DMBT1) encoding a large scavenger receptor cysteine-rich protein was originally identified based on its deletion in a brain tumor cell line. The DMBT1 protein is involved in mucosal immune defense, epithelial differentiation and tumor suppression. In the present study, the clinicopathologic significance of DMBT1 protein expression in stool and tissue samples of colorectal cancer (CRC) patients was evaluated. Western blot analysis of fecal DMBT1 was pe