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Biophysical Derangements in Genetic Cardiomyopathies.

Heart Fail Clin; 14(2): 147-159, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29525644
This article focuses on three "bins" that comprise sets of biophysical derangements elicited by cardiomyopathy-associated mutations in the myofilament. Current therapies focus on symptom palliation and do not address the disease at its core. We and others have proposed that a more nuanced classification could lead to direct interventions based on early dysregulation changing the trajectory of disease progression in the preclinical cohort. Continued research is necessary to address the complexity of cardiomyopathic progression and develop efficacious therapeutics.