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Mast Cells Exert Anti-Inflammatory Effects in an IL10 Model of Spontaneous Colitis.

Mediators Inflamm; 2018: 7817360, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29849494
Mast cells are well established as divergent modulators of inflammation and immunosuppression, but their role in inflammatory bowel disease (IBD) remains to be fully defined. While previous studies have demonstrated a proinflammatory role for mast cells in acute models of chemical colitis, more recent investigations have shown that mast cell deficiency can exacerbate inflammation in spontaneous colitis models, thus suggesting a potential anti-inflammatory role of mast cells in IBD. Here, we test