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Hydroxyproline attenuates dextran sulfate sodium-induced colitis in mice: involvment of the NF-κB signaling and oxidative stress.

Mol Nutr Food Res; : e1800494, 2018 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-30184329
SCOPE: Inflammatory bowel disease (IBD) is a chronic disease of gastrointestinal tract in which oxidative stress and overactivation of inflammatory response are implicated. The aim of the present study was to test the hypothesis that hydroxyproline (Hyp), an amino acid with an antioxidative property, attenuates DSS-induced colitis in mice.


Male C57BL/6 supplemented with or without 1% Hyp were subjected to 2.5% DSS to induce colitis. Hyp attenuated the severity of colitis as evidenced by reduced disease activity index scores, decreased myeloperoxidase activity, histological damage, and apoptosis. Furthermore, DSS-induced increases in ROS accumulation, TNF-α and IL-6 secretion, and MDA activity, reduced GSH level were ameliorated by Hyp. The enhanced phosphorylation of STAT3 and NF-κB following DSS administration was mitigated by Hyp, which was also observed in LPS-treated RAW264.7 macrophages. Moreover, the inhibitory effect of Hyp on IL-6 was mainly mediated by NF-κB signaling, because the induction of STAT3 and IL-6 following LPS treatment was markedly reversed by Bay11-7085, a specific inhibitor of NF-κB.


In summary, Hyp is a critical nutrient with an ability to attenuate DSS-induced colonic damage in mice. This beneficial effect of Hyp was partially mediated by inhibiting NF-κB/IL-6 signalling and restoration of redox homeostasis. This article is protected by copyright. All rights reserved.