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Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus Stachybotrys chartarum.

J Asian Nat Prod Res; : 1-8, 2019 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-30614271
Three new phenylspirodrimanes derivatives named stachybotrysins H and I (1 and 2) and stachybotrin E (3), together with one known compound stachybotrylactam (4), were isolated from Stachybotrys chartarum CGMCC 3.5365. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 1 and 2 showed inhibitory effect towards potassium channel Kv1.3 with IC values of 13.4 and 10.9 µM, respectively. [Formula: see text].