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Solanrubiellin A, a hydroanthraquinone dimer with antibacterial and cytotoxic activity from Solanum lyratum.

Nat Prod Res; : 1-6, 2019 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-30618289
A new hydroanthraquinone dimer derivative, solanrubiellin A, was isolated from the whole plants of Solanum lyratum. The structure of 1 was established through extensive NMR spectroscopy analysis, and the absolute configuration was elucidated by comparison of its experimental and calculated ECD spectra. Compound 1 showed antibacterial activity with MIC values of 2-10 µM against several Gram-positive bacteria. Compound 1 also demonstrated cytotoxic activity against human A549, HT-29 and HL-60 cell lines with IC50 values ranging from 2.06 to 9.35 µM.