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Prostate-specific membrane antigen radioligand therapy of prostate cancer.

Q J Nucl Med Mol Imaging; 63(1): 29-36, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30644306
Defining an optimal therapeutic approach in metastatic castration-resistance prostate cancer (mCRPC) patients in advanced stages is still challenging in routine clinical practice. Prostate-specific membrane antigen (PSMA) targeted radionuclide therapy with ß- or α-emitters such as 177-Lutethium (177Lu) or 225-Actinium (225A) has been a main focus at multiple academic research centers in the last few years. This review article provides an overview of PSMA characteristics, clinical performance, safety and toxicity of PSMA targeted ß- or α-radiation therapy.