Your browser doesn't support javascript.

Portal Regional da BVS

Informação e Conhecimento para a Saúde

Home > Pesquisa > ()
XML
Imprimir Exportar

Formato de exportação:

Exportar

Email
Adicionar mais destinatários
| |

A Multifunctional Peptide-Conjugated AIEgen for Efficient and Sequential Targeted Gene Delivery into the Nucleus.

Angew Chem Int Ed Engl; 58(15): 5049-5053, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30767348
Gene therapy has immense potential as a therapeutic approach to serious diseases. However, efficient delivery and real-time tracking of gene therapeutic agents have not been solved well for successful gene-based therapeutics. Herein we present a versatile gene-delivery strategy for efficient and visualized delivery of therapeutic genes into the targeted nucleus. We developed an integrin-targeted, cell-permeable, and nucleocytoplasmic trafficking peptide-conjugated AIEgen named T NCP for the efficient and sequential targeted delivery of an antisense single-stranded DNA oligonucleotide (ASO) and tracking of the delivery process into the nucleus. As compared with T NCP/siRNA-NPs (siRNA functions mainly in the cytoplasm), T NCP/ASO-NPs (ASO functions mainly in the nucleus) exhibited a better interference effect, which further indicates that T NCP is a nucleus-targeting vector. Moreover, T NCP/ASO-NPs showed a favorable tumor-suppressive effect in vivo.