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Recent Progress on Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers.

Curr Top Med Chem; 2019 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-31074370
Sirtuins family is a class of NDA+ dependent protein deacetylases that plays a key role in the regulation of several aspects of biological processes, such as cell cycle regulation, autophagy, immune and inflammatory response. Many studies have shown that sirtuins2 as a key player in the cancer pathway is of great significance in tumorigenesis, this review summarizes the newly discovered in recent years some SIRT2 inhibitors for cancer target structure, action mechanism, biological activity, substrate specificity, and signaling pathways.