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Atorvastatin and hormone therapy effects on APOE mRNA expression in hypercholesterolemic postmenopausal women
Issa, Mustafa H; Cerda, Alvaro; Genvigir, Fabiana D. V; Cavalli, Selma A; Bertolami, Marcelo C; Faludi, Andre A; Hirata, Mario H; Hirata, Rosario D. C.
Afiliação
  • Issa, Mustafa H; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo. São Paulo. BR
  • Cerda, Alvaro; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo. São Paulo. BR
  • Genvigir, Fabiana D. V; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo. São Paulo. BR
  • Cavalli, Selma A; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo. São Paulo. BR
  • Bertolami, Marcelo C; Dante Pazzanese Institute of Cardiology. São Paulo. BR
  • Faludi, Andre A; Dante Pazzanese Institute of Cardiology. São Paulo. BR
  • Hirata, Mario H; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo. São Paulo. BR
  • Hirata, Rosario D. C; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo. São Paulo. BR
Journal of Steroid Biochemistry Biology ; 128: 139-144, 2012. tab, graf
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1064352
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT
Menopause is associated with changes in lipid levels resulting in increased risk of atherosclerosis andcardiovascular events. Hormone therapy (HT) and atorvastatin have been used to improve lipid profilein postmenopausal women.Effects of HT, atorvastatin and APOE polymorphisms on serum lipids and APOE and LXRA expressionwere evaluated in 87 hypercholesterolemic postmenopausal women, randomly selected for treatmentwith atorvastatin (AT, n = 17), estrogen or estrogen plus progestagen (HT, n = 34) and estrogen or estrogenplus progestagen associated with atorvastatin (HT + AT, n = 36). RNA was extracted from peripheralblood mononuclear cells (PBMC) and mRNA expression was measured by TaqMan® PCR. APOE 2/ 3/ 4genotyping was performed using PCR-RFLP.Total cholesterol (TC), LDL-c and apoB were reduced after each treatment (p < 0.001). Triglycerides,VLDL-c and apoAI were reduced only after atorvastatin (p < 0.05), whereas triglycerides and VLDL-c wereincreased after HT (p = 0.01). HT women had lower reduction on TC, LDL-c and apoB than AT and HT + ATgroups (p < 0.05). APOE mRNA expression was reduced after atorvastatin treatment (p = 0.03). AlthoughLXRA gene expression was not modified by atorvastatin, it was correlated with APOE mRNA before andafter treatments. Basal APOE mRNA expression was not influenced by gene polymorphisms, however thereduction on APOE expression was more pronounced in 3 3 than in 3 4 carriers.Atorvastatin down-regulates APOE mRNA expression and it is modified by APOE genotypes in PBMCfrom postmenopausal women.
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Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Menopausa / Terapia de Reposição Hormonal / Polimorfismo de Nucleotídeo Único / Genética Idioma: Inglês Revista: Journal of Steroid Biochemistry Biology Ano de publicação: 2012 Tipo de documento: Artigo Instituição/País de afiliação: Dante Pazzanese Institute of Cardiology/BR / Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo/BR
Buscar no Google
Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Menopausa / Terapia de Reposição Hormonal / Polimorfismo de Nucleotídeo Único / Genética Idioma: Inglês Revista: Journal of Steroid Biochemistry Biology Ano de publicação: 2012 Tipo de documento: Artigo Instituição/País de afiliação: Dante Pazzanese Institute of Cardiology/BR / Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo/BR
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