Pharmacogenetics of OATP Transporters Reveals That SLCO1B1 c.388A>G Variant Is Determinant of Increased Atorvastatin Response
Int J Mol Sci
; 12(9): 5815-5827, 2011. ilus, tab
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1063493
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
Aims:
The relationship between variants in SLCO1B1 and SLCO2B1 genes and lipid-lowering response to atorvastatin was investigated. Material andMethods:
One-hundred-thirty-six unrelated individuals with hypercholesterolemia were selected andOPEN ACCESStreated with atorvastatin (10 mg/day/4 weeks). They were genotyped with a panel of ancestry informative markers for individual African component of ancestry (ACA) estimation by SNaPshot® and SLCO1B1 (c.388A>G, c.463C>A and c.521T>C) and SLCO2B1 (−71T>C) gene polymorphisms were identified by TaqMan® Real-time PCR.Results:
Subjects carrying SLCO1B1 c.388GG genotype exhibited significantly high low-density lipoprotein (LDL) cholesterol reduction relative to c.388AA+c.388AG carriers (41 vs. 37%, p = 0.034). Haplotype analysis revealed that homozygous of SLCO1B1*15 (c.521C and c.388G) variant had similar response to statin relative to heterozygous and non-carriers. A multivariate logistic regression analysis confirmed that c.388GG genotype was associated with higher LDL cholesterol reduction in the study population (OR 3.2, CI95%1.38.0, p G polymorphism causes significant increase in atorvastatin response and may be an important marker for predicting efficacy of lipid-lowering therapy.
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Farmacogenética
/
Polimorfismo de Nucleotídeo Único
Idioma:
Inglês
Revista:
Int J Mol Sci
Ano de publicação:
2011
Tipo de documento:
Artigo
Instituição/País de afiliação:
Faculdade de Ciências Farmacêuticas da Universidade de São Paulo/BR
/
Forensic Genetics Unit, Institute of Legal Medicine, University of Santiago de Compostela/ES
/
Hospital Universitário da Universidade de São Paulo/BR
/
Instituto Dante Pazzanese de Cardiologia/BR
/
Life Technologies/BR
/
University of Aveiro/PT