Predictive Potential of Twenty-Two Biochemical Biomarkers forCoronary Artery Disease in Type 2 Diabetes Mellitus
J. clin. endocrinol. metab
; 2015: 1-8, 2015. ilus
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1063835
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
We investigated the potential of a panel of 22 biomarkers to predict the presence of coronary artery disease (CAD) in type 2diabetes mellitus (DM2) patients. The study enrolled 96 DM2 patients with (n = 75) and without (n = 21) evidence of CAD.We assessed a biochemical profile that included 22 biomarkers total cholesterol, LDL, HDL, LDL/HDL, triglycerides, glucose,glycated hemoglobin, fructosamine, homocysteine, cysteine, methionine, reduced glutathione, oxidized glutathione, reducedglutathione/oxidized glutathione, L-arginine, asymmetric dimethyl-L-arginine, symmetric dimethyl-L-arginine, asymmetricdimethyl-L-arginine/L-arginine, nitrate plus nitrite, S-nitrosothiols, nitrotyrosine, and n-acetyl-𝛽-glucosaminidase. Predictionmodels were built using logistic regression models.We found that eight biomarkers (methionine, nitratate plus nitrite, n-acetyl-𝛽-glucosaminidase, BMI, LDL, HDL, reduced glutathione, and L-arginine/asymmetric dimethyl-L-arginine) along with gender andBMI were significantly associated with the odds of CAD in DM2. These preliminary findings support the notion that emergingbiochemical markers might be used for CAD prediction in patients with DM2. Our findings warrant further investigation withlarge, well-designed studies.
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Doença da Artéria Coronariana
/
Diabetes Mellitus
/
Infarto
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
J. clin. endocrinol. metab
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Faculdade de Ciências Farmacêuticas, Universidade de São Paulo/BR
/
Faculdade de Ciências Médicas, Universidade Metodista de Santos/BR
/
Hospital Alemão Oswaldo Cruz/BR
/
Instituto Dante Pazzanese de Cardiologia/BR
/
Santa Casa de Misericórdia de São Paulo/BR