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Outcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial
Jolly, Sanjit S; Cairns, John A; Yusuf, Salim; Rokoss, Michael J; Gao, Peggy; Meeks, Brandi; Kedev, Sasko; Stankovic, Goran; Moreno, Raul; Gershlick, Anthony; Chowdhary, Saqib; Lavi, Shahar; Niemela, Kari; Bernat, Ivo; Cantor, Warren J; Cheema, Asim N; Steg, Philippe Gabriel; Welsh, Robert C; Sheth , Tej; Bertrand, Olivier F; Avezum, Alvaro; Bhindi, Ravinay; Natarajan, Madhu K; Horak, David; Leung, Raymond CM; Kassam, Saleem; Rao, Sunil V; El-Omar, Magdi; Mehta, Shamir R; Velianou, James L; Pancholy, Samir; Džavík, Vladimír.
Afiliação
  • Jolly, Sanjit S; McMaster University and the Population Health Research Institute. Hamilton Health Sciences. Hamilton, ON. CA
  • Cairns, John A; University of British Columbia. Vancouver, BC. CA
  • Yusuf, Salim; McMaster University and the Population Health Research Institute. Hamilton Health Sciences. Hamilton, ON. CA
  • Rokoss, Michael J; McMaster University and the Population Health Research Institute. Hamilton Health Sciences. Hamilton, ON. CA
  • Gao, Peggy; McMaster University and the Population Health Research Institute. Hamilton Health Sciences. Hamilton, ON. CA
  • Meeks, Brandi; McMaster University and the Population Health Research Institute. Hamilton Health Sciences. Hamilton, ON. CA
  • Kedev, Sasko; University Clinic of Cardiology. Sts. Cyril and Methodius University. Skopje. MK
  • Stankovic, Goran; University Clinic of Cardiology. Sts. Cyril and Methodius University. Skopje. MK
  • Moreno, Raul; University Hospital La Paz. Madrid. ES
  • Gershlick, Anthony; University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit. University Hospitals of Leicester NHS Trust. Leicester. GB
  • Chowdhary, Saqib; University Hospitals South Manchester. Manchester Academic Health Science Centre. Manchester. GB
  • Lavi, Shahar; London Health Sciences Centre, Department of Medicine. London, ON. CA
  • Niemela, Kari; Heart Center, Tampere University Hospital. Tampere. FI
  • Bernat, Ivo; University Hospital and Faculty of Medicine Pilsen. Pilsen. CZ
  • Cantor, Warren J; Southlake Regional Health Centre. Newmarket, ON. CA
  • Cheema, Asim N; St Michael's Hospital. Toronto, ON. CA
  • Steg, Philippe Gabriel; Université Paris-Diderot. Hôpital Bichat. Paris. FR
  • Welsh, Robert C; Mazankowski Alberta Heart Institute. Edmonton, A B. CA
  • Sheth , Tej; McMaster University and the Population Health Research Institute. Hamilton Health Sciences. Hamilton, ON. CA
  • Bertrand, Olivier F; Quebec Heart–Lung Institute. Laval University. Quebec. CA
  • Avezum, Alvaro; Dante Pazzanese Institute of Cardiology. University of Santo Amaro. São Paulo. BR
  • Bhindi, Ravinay; Royal North Shore Hospital. Sydney. AU
  • Natarajan, Madhu K; McMaster University and the Population Health Research Institute. Hamilton Health Sciences. Hamilton, ON. CA
  • Horak, David; Krajská Nemocnice Liberec. Liberec. CZ
  • Leung, Raymond CM; CK Hui Heart Centre. Edmonton, AB. CA
  • Kassam, Saleem; Rouge Valley Health System. Toronto, ON. CA
  • Rao, Sunil V; Duke Clinical Research Institute. Durham, NC. US
  • El-Omar, Magdi; Central Manchester Foundation Trust. Manchester Academic Health Science Centre. Manchester. GB
  • Mehta, Shamir R; McMaster University and the Population Health Research Institute. Hamilton Health Sciences. Hamilton, ON. CA
  • Velianou, James L; McMaster University and the Population Health Research Institute. Hamilton Health Sciences. Hamilton, ON. CA
  • Pancholy, Samir; Northeast Clinical Trials Group. Scranton, PA. US
  • Džavík, Vladimír; Peter Munk Cardiac Centre, University Health Network. Toronto, ON. CA
Lancet ; 387(10014): 127-135, 2016.
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1064586
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT
BackgroundTwo large trials have reported contradictory results at 1 year after thrombus aspiration in ST elevation myocardial infarction (STEMI). In a 1-year follow-up of the largest randomised trial of thrombus aspiration, we aimed to clarify the longer-term benefits, to help guide clinical practice.MethodsThe trial of routine aspiration ThrOmbecTomy with PCI versus PCI ALone in Patients with STEMI (TOTAL) was a prospective, randomised, investigator-initiated trial of routine manual thrombectomy versus percutaneous coronary intervention (PCI) alone in 10 732 patients with STEMI. Eligible adult patients (aged ≥18 years) from 87 hospitals in 20 countries were enrolled and randomly assigned (11) within 12 h of symptom onset to receive routine manual thrombectomy with PCI or PCI alone. Permuted block randomisation (with variable block size) was done by a 24 h computerised central system, and was stratified by centre. Participants and investigators were not masked to treatment assignment. The trial did not show a difference at 180 days in the primary outcome of cardiovascular death, myocardial infarction, cardiogenic shock, or heart failure. However, the results showed improvements in the surrogate outcomes of ST segment resolution and distal embolisation, but whether or not this finding would translate into a longer term benefit remained unclear...
Assuntos
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Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Trombose / Trombectomia / Intervenção Coronária Percutânea Tipo de estudo: Ensaio clínico controlado / Guia de prática clínica Idioma: Inglês Revista: Lancet Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: CK Hui Heart Centre/CA / Central Manchester Foundation Trust/GB / Dante Pazzanese Institute of Cardiology/BR / Duke Clinical Research Institute/US / Heart Center, Tampere University Hospital/FI / Krajská Nemocnice Liberec/CZ / London Health Sciences Centre, Department of Medicine/CA / Mazankowski Alberta Heart Institute/CA / McMaster University and the Population Health Research Institute/CA / Northeast Clinical Trials Group/US
Buscar no Google
Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Trombose / Trombectomia / Intervenção Coronária Percutânea Tipo de estudo: Ensaio clínico controlado / Guia de prática clínica Idioma: Inglês Revista: Lancet Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: CK Hui Heart Centre/CA / Central Manchester Foundation Trust/GB / Dante Pazzanese Institute of Cardiology/BR / Duke Clinical Research Institute/US / Heart Center, Tampere University Hospital/FI / Krajská Nemocnice Liberec/CZ / London Health Sciences Centre, Department of Medicine/CA / Mazankowski Alberta Heart Institute/CA / McMaster University and the Population Health Research Institute/CA / Northeast Clinical Trials Group/US
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