Prevalence, predictors, and prognostic implications of residual impairment of functional capacity after transcatheter aortic valve implantation
Clin. res. cardiol
; 106(9): 752-759, 2017. tab, graf
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1062078
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
Background Patients with degenerative aortic stenosis(AS) referred for transcatheter aortic valve implantation(TAVI) typically have advanced cardiac and vascular adverse remodeling and multiple comorbidities and,therefore, might not recover a normal functional capacity after valve replacement. We sought to investigate the prevalence, the predictors, and the prognostic impact of residual impairment of functional capacity after TAVI. Methods and results Out of 790 patients undergoing TAVI with impaired functional capacity (NYHA IIIV) at baseline, NYHA functional class improved in 592 (86.5%) andremained unchanged/worsened in 92 (13.5%) at follow-up[median (IQR) 419 (208807) days] after TAVI. Normal functional capacity (NYHA I) was recovered in 65.5%(n = 448) of patients, while the rest had variable degrees of residual impairment. On multivariable regression analysis,atrial fibrillation [odds ratio-OR, 2.08 (1.213.58), p = 0.008],low-flowlow-gradient AS [OR, 1.97 (1.093.57),p = 0.026], chronic obstructive pulmonary disease [OR, 1.92(1.193.12), p = 0.008], and lower hemoglobin at baseline[OR, 1.11 (1.011.21) for each g% decrement, p = 0.036]were independently associated with residual impairment offunctional capacity. All-cause and cardiac mortality weresignificantly higher in those with residual impairment of functional capacity than in those in NYHA I class [hazard ratioHR2.37 (95% CI 1.513.72), p/0.001 and 2.16 (95% CI1.084.35), p = 0.030, respectively]. Even mild residual functional impairment (NYHA II) was associated with a higherall-cause [HR 2.02 (95% CI 1.103.72), p = 0.023] andcardiac [HR 2.08 (95% CI 1.423.07), p/0.001] mortality. Conclusion Residual impairment of functional capacity iscommon after TAVI and is independently associated with increased mortality. Predictors of residual impairment of functional status are predominantly patient-rather than procedure-related.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Estenose da Valva Aórtica
/
Qualidade de Vida
Tipo de estudo:
Estudo de prevalência
/
Estudo prognóstico
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Fatores de risco
Aspecto:
Preferência do paciente
Idioma:
Inglês
Revista:
Clin. res. cardiol
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Erasmus Medical Center/NL
/
Hospital Beneficência Portuguesa de São Paulo/BR
/
Hospital Israelita Albert Einstein/BR
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Instituto Dante Pazzanese de Cardiologia/BR
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Instituto de Cardiologia do Rio Grande do Sul/BR
/
Instituto do Coração/BR
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International Centre for Circulatory Health/GB
/
University of Amsterdam/DE