First-in-human evaluation of a novel polymer-free drug-filled stent: angiographic, IVUS, OCT, and clinical outcomes from the RevElution study
JACC cardiovasc. interv
; 10(2): 147-156, 2017. graf, ilus, tab
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1064052
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
OBJECTIVES:
This study sought to assess the safety and effectiveness of the drug-filled stent (DFS) (Medtronic, Santa Rosa, California) in the treatment of patients with coronary artery disease.BACKGROUND:
Polymer-free drug-eluting stents have the potential to improve clinical outcomes and facilitate shorter durations of dual antiplatelet therapy. The polymer-free DFS is made from a trilayered continuous wire with an outer cobalt chromium layer, a middle tantalum layer, and an inner lumen coated with sirolimus. Small laser-drilled holes on the abluminal stent surface control drug elution.METHODS:
The RevElution trial enrolled 100 patients with de novo coronary lesions 2.25 to 3.50 mm in diameter and length ≤27 mm in 2 cohorts of 50 patients for angiographic, intravascular ultrasound, and clinical assessment at 9 or 24 months, with optical coherence tomography performed in a subset of 30 patients at each time period. The primary endpoint was angiographic in-stent late lumen loss at 9 months compared with Resolute zotarolimus-eluting stent (Medtronic) historical control data...
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Stents Farmacológicos
/
Intervenção Coronária Percutânea
Idioma:
Inglês
Revista:
JACC cardiovasc. interv
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Bern University Hospital/CH
/
Cardiovascular Research Centre, Royal Adelaide Hospital/AU
/
Clinical Research Department, Medtronic,/US
/
Fiona Stanley Hospital/AU
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Heart and Vascular Institute, Flinders Medical Centre/AU
/
Hospital and the Cardiovascular Research Foundation/US
/
Instituto Dante Pazzanese de Cardiologia/BR
/
MonashHealth and Monash University/AU
/
The study was funded by Medtronic/US
/
University Hospitals Cleveland Medical Center/US