Risk and timing of clinical events according to diabetic status of patients treated with everolimus-eluting bioresorbable vascular scaffolds versus everolimus-eluting stent: 2-year results from a propensity score matched comparison of ABSORB EXTEND and SPIRIT trials
Catheter Cardiovasc Interv
; 91(3): 387-395, 2018. tab, graf
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1061866
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
OBJECTIVES:
to compare the occurrence of clinical events in diabetics treated with the Absorb bioresorbable vascular scaffold (Absorb BVS; Abbott Vascular, Santa Clara, CA) versus everolimus-eluting metal stents (EES; XIENCE V; Abbott Vascular, Santa Clara, CA)BACKGROUND:
There are limited data dedicated to clinical outcomes of diabetic patients treated with bioresorbable scaffolds (BRS) at 2-year horizon.METHODS:
The present study included 812 patients in the ABSORB EXTEND study in which a total of 215 diabetic patients were treated with Absorb BVS. In addition, 882 diabetic patients treated with EES in pooled data from the SPIRIT clinical program (SPIRIT II, SPIRIT III and SPIRIT IV trials) were used for comparison by applying propensity score matching using 29 different variables. The primary endpoint was ischemia driven major adverse cardiac events (ID-MACE), including cardiac death, myocardial infarction (MI), and ischemia driven target lesion revascularization (ID-TLR).RESULTS:
After 2 years, the ID-MACE rate was 6.5% in the Absorb BVS vs. 8.9% in the Xience group (P = 0.40). There was no difference for MACE components or definite/probable device thrombosis (HR 1.43 [0.24,8.58]; P = 0.69). The occurrence of MACE was not different for both diabetic status (insulin- and non-insulin-requiring diabetes) in all time points up to the 2-year follow-up for the Absorb and Xience groups...
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Stents
/
Stents Farmacológicos
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Coração
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Idioma:
Inglês
Revista:
Catheter Cardiovasc Interv
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Centro Cardiologico Monzino, IRCCS/IT
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Department of Cardiology, Cardiovascular Center Aalst/BE
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Department of Cardiology, Chang Gung Memorial Hospital/TW
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Department of Cardiology, Hospital Israelita Albert Einstein/BR
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Department of Cardiology, Hôpital de Rangueil CHU/FR
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Department of Cardiology, Institute Jantung Negara/MY
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Department of Cardiology, National Taiwan University Hospital/TW
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Department of Cardiology, St Vincent's Hospital/AU
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Department of Interventional Cardiology, Columbia University Medical Center/US
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Instituto Dante Pazzanese de Cardiologia/BR