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Claudin-3 and occludin content in the glands of colonic mucosa devoid from fecal stream submitted to topical intervention with oil extract of Curcuma longa
Martinez, Carlos Augusto Real; Kadri, Caled Jaoudat; Kanno, Danilo Toshio; Alves Júnior, Antônio José Tibúrcio; Coy, Cláudio Saddy Rodrigues; Pereira, José Aires.
Afiliação
  • Martinez, Carlos Augusto Real; Universidade São Francisco. Bragança Paulista. Brazil
  • Kadri, Caled Jaoudat; Universidade São Francisco. School of Medicine. Bragança Paulista. Brazil
  • Kanno, Danilo Toshio; Universidade São Francisco. Bragança Paulista. Brazil
  • Alves Júnior, Antônio José Tibúrcio; Universidade de Campinas. Campinas. Brazil
  • Coy, Cláudio Saddy Rodrigues; Universidade de Campinas. Department of Surgery. Campinas. Brazil
  • Pereira, José Aires; Universidade São Francisco. School of Medicine. Bragança Paulista. Brazil
Acta cir. bras. ; 32(1): 65-73, Jan. 2017. ilus
Artigo em Inglês | VETINDEX | ID: vti-684367
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT

Purpose:

To evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin.

Methods:

Thirty-six rats were submitted to a proximal colostomy and a distal mucous fistula and divided into two groups according to sacrifice to be performed two or four weeks. Each group was divided into three subgroups according daily application of enemas containing saline, curcumin at 50 mg/kg/day or 200 mg/kg/day. Colitis was diagnosed by histological analysis. Claudin-3 and occludin were determined by immunohistochemistry. The tissue content of claudin-3 and occludin were quantified by computer-assisted image analysis. Mann-Whitney, Student t and ANOVA tests were used to analyze the results establishing the level of significance of 5% for both (p 0.05).

Results:

Curcumin at both concentrations reduces the inflammation and preserves the tissue content of the proteins claudin-3 and occludin, which was related to the concentration used and to the time of the intervention.

Conclusion:

The application of enemas with curcumin reduces inflammation and preserves the tissue content of the proteins claudin-3 and occludin in the colonic mucosa devoid from the fecal stream.(AU)
Assuntos


Texto completo: Disponível Base de dados: VETINDEX Assunto principal: Colite / Curcuma / Ocludina / Claudina-3 Limite: Animais Idioma: Inglês Revista: Acta cir. bras. Ano de publicação: 2017 Tipo de documento: Artigo / Documento de projeto Instituição/País de afiliação: Universidade São Francisco/Brazil / Universidade de Campinas/Brazil

Texto completo: Disponível Base de dados: VETINDEX Assunto principal: Colite / Curcuma / Ocludina / Claudina-3 Limite: Animais Idioma: Inglês Revista: Acta cir. bras. Ano de publicação: 2017 Tipo de documento: Artigo / Documento de projeto Instituição/País de afiliação: Universidade São Francisco/Brazil / Universidade de Campinas/Brazil
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