Proteostasis and
oxidative stress were evaluated in
motor cortex and
spinal cord of
aged Lewis
rats exposed to 1mg/kg/day of
rotenone during 4 or 8weeks, prior or after practicing three
protocols of mild treadmill
running . Results demonstrated that
exercise done after the beginning of neurodegeneration reverted the increased
oxidative stress (measured by H2O2 levels and SOD activity), increased
neuron strength, and improved
proteostasis in
motor cortex .
Spinal cord was not affected. Treadmill
running practiced before neurodegeneration protected cortical
motor neurons of the
rotenone -exposed
rats ; but in this case,
oxidative stress was not altered, whereas
proteasome activity was increased and
autophagy decreased.
Spinal cord was not protected when
exercise was practiced before neurodegeneration. Prolonged treadmill
running (10weeks) increased
oxidative stress ,
autophagy , and
proteasome activity, whereas
neuron viability was decreased in
motor cortex . In
spinal cord , this protocol decreased
oxidative stress and increased
proteasome activity. Major conclusions were that treadmill
running practiced before or after the beginning of neurodegeneration may protect
motor cortex neurons , whereas prolonged mild
running seems to be beneficial for
spinal cord .