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Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.

Li, Hao; Kayani, Masood ur Rehman; Gu, Yunting; Wang, Xiaobo; Zhu, Ting; Duan, Hongfei; Ma, Yifeng; Huang, Hairong; Javid, Babak.
J Clin Microbiol; 53(8): 2781-4, 2015 Aug.
Artigo Inglês | MEDLINE | ID: mdl-26063862

Resumo

Drug resistance to tuberculosis remains a major public health threat. Here, we report two cases of extended-spectrum extensively drug-resistant (XXDR) tuberculosis showing resistance to most first- and second-line agents. The results of a correlation of whole-genome sequencing (WGS) and phenotypic testing were discordant, suggesting that overreliance on WGS may miss clinically relevant resistance in extensively drug-resistant disease.
Selo DaSilva