Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil
BMC Infectious Diseases
; 17: 1-13, 15 ago. 2017. tab, graf
Article
em En
| SES-SP, SESSP-ACVSES, SESSP-ICFPROD, SES-SP
| ID: biblio-1060402
Biblioteca responsável:
BR91.2
Localização: BR91.2; Digital
ABSTRACT
Background:
The implementation of rapid drug susceptibility testing (DST) is a current global priority for TBcontrol. However, data are scarce on patient-relevant outcomes for presumptive diagnosis of drug-resistanttuberculosis (pDR-TB) evaluated under field conditions in high burden countries.Methods:
Observational study of pDR-TB patients referred by primary and secondary health units. TB referencecenters addressing DR-TB in five cities in Brazil. Patients age 18 years and older were eligible if pDR-TB, culturepositive results for Mycobacterium tuberculosis and, if no prior DST results from another laboratory were used by aphysician to start anti-TB treatment. The outcome measures were median time from triage to initiating appropriateanti-TB treatment, empirical treatment and, the treatment outcomes.Results:
Between February,16th, 2011 and February, 15th, 2012, among 175 pDR TB cases, 110 (63.0%) confirmed TBcases with DST results were enrolled. Among study participants, 72 (65.5%) were male and 62 (56.4%) aged 26 to45 years. At triage, empirical treatment was given to 106 (96.0%) subjects. Among those, 85 were treated with firstline drugs and 21 with second line. Median time for DST results was 69.5 [interquartile - IQR 35.7111.0] days and,for initiating appropriate anti-TB treatment, the median time was 1.0 (IQR 041.2) days. Among 95 patients thatwere followed-up during the first 6 month period, 24 (25.3%; IC 17.5%34.9%) changed or initiated the treatmentafter DSTresults:
16/29 MDRTB, 5/21 DR-TB and 3/45 DS-TB cases. Comparing the treatment outcome to DS-TBcases, MDRTB had higher proportions changing or initiating treatment after DST results (p = 0.01) and favorableoutcomes (p = 0.07).Conclusions:
This study shows a high rate of empirical treatment and long delay for DST results. Strategies tospeed up the detection and early treatment of drug resistant TB should be prioritized.Palavras-chave
Texto completo:
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Coleção SES:
Acervo_geral
/
Producao_cientifica
Base de dados:
SES-SP
/
SESSP-ACVSES
/
SESSP-ICFPROD
Assunto principal:
Tuberculose
/
Brasil
/
Resultado do Tratamento
/
Tuberculose Resistente a Múltiplos Medicamentos
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Male
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article