The obtainment of
monoclonal antibodies for
adenovirus species 4(Ad4) is described. The specificities of selected
monoclonal antibodies were determined by means of viral
neutralization test in
cell culture,
immunofluorescence and
Enzyme-Linked Immunosorbent Assay (
ELISA), in the presence of the following species of
human adenovirus 1, 2, 5 (subgenus C), 4 (subgenus E), 7 and 16 (subgenus B) and 9 (subgenus D). Two
monoclonal antibodies species specific to
adenovirus 4 (1CIII and 3DIII) and one
monoclonal antibody that cross reacted with
adenovirus species 4 and 7 (2HIII) were obtained.