Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV
Machado, Daisy Maria; Fink, Maria Cristina; Pannuti, Cláudio Sérgio; Succi, Regina Célia de Menezes; Machado, Alessandra Aparecida; Carmo, Fabiana Bononi do; Gouvêa, Aída de Fátima Barbosa; Urbano, Paulo Roberto; Beltrão, Suenia Vasconcelos; Santos, Isabel Cristina Lopes dos; Machado, Clarisse Martins.
Mem. Inst. Oswaldo Cruz
; 106(8): 931-935, Dec. 2011. graf, tab
Artigo
em Inglês
| LILACS | ID: lil-610966
The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4 percent and 40.4 percent, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6 percent and 54.3 percent of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5 percent of subjects and for BKV in 12.5 percent of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9 percent) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance.
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