Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda
Rocha, Cláudia Q. da; Vilela, Fabiana C.; Santa-Cecília, Flávia V.; Cavalcante, Gustavo P.; Vilegas, Wagner; Giusti-Paiva, Alexandre; Santos, Marcelo H. dos.
Rev. bras. farmacogn
; 25(3): 228-232, May-June 2015. tab, ilus
Artigo
em Inglês
| LILACS | ID: lil-757434
AbstractArrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3β-estearioxy-olean-12-ene in animals. We observed that 3β-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3β-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect in different tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use.
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