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Chagasic meningoencephalitis: case report of a recently included AIDS-defining illness in Brazil.

Madalosso, Geraldine; Pellini, Alessandra C Guedes; Vasconcelos, Marileide J; Ribeiro, Ana Freitas; Weissmann, Leonardo; Oliveira Filho, Gilberto Silva; Penalva de Oliveira, Augusto C; Vidal, Jose E.
Rev Inst Med Trop Sao Paulo; 46(4): 199-202, 2004 Jul-Aug.
Artigo em Inglês | MEDLINE | ID: mdl-15361971
Recently, reactivation of Chagas disease (meningoencephalitis and/or myocarditis) was included in the list of AIDS-defining illnesses in Brazil. We report a case of a 52-year-old patient with no history of previous disease who presented acute meningoencephalitis. Direct examination of blood and cerebrospinal fluid (CSF) showed Trypanosoma cruzi. CSF culture confirmed the diagnosis. Serological assays for T. cruzi and human immunodeficiency virus (HIV) were positive. Despite treatment with benznidazol and supportive measures, the patient died 24 hours after hospital admission. In endemic areas, reactivation of Chagas disease should always be considered in the differential diagnosis of meningoencephalitis among HIV-infected patients, and its presence is indicative of AIDS.