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Angiosarcoma in HIV-negative patients is not associated with HHV-8.

Avancini, João; Sanches, José Antonio; Cherubim, Andre Pires Zanata; Pazzini, Renato; Oliveira, Cristina Mendes de; Sumita, Laura Masami; Valente, Neusa Yuriko Sakai; Pannuti, Claudio Sergio; Festa, Cyro.
An Bras Dermatol; 91(6): 738-741, 2016 Nov-Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28099593

BACKGROUND:

: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined.

OBJECTIVE:

: To investigate the relationship between the presence of HHV-8 and angiosarcoma.

METHODS:

: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls.

RESULTS:

: While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was.

CONCLUSION:

: These findings support most previous studies that found no association between HHV-8 and angiosarcoma.