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Epidemiology and molecular characterization of Neisseria lactamica carried in 11-19 years old students in Salvador, Brazil.

Moura, Ana Rafaela Silva Simões; Kretz, Cécilia Batmalle; Ferreira, Ítalo Eustáquio; Nunes, Amélia Maria Pithon Borges; de Filippis, Ivano; de Moraes, José Cássio; Reis, Mitermayer Galvão; McBride, Alan John Alexander; Wang, Xin; Campos, Leila Carvalho.
Int J Med Microbiol; 308(4): 454-458, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29605532
Neisseria lactamica is a nonpathogenic commensal bacterium that is potentially associated with the development of natural immunity against N. meningitidis. However, the genetic variation present in natural populations of N. lactamica has not been fully investigated. To better understand its epidemiology and genetic variation, we studied N. lactamica carriage in 1200 students aged 11-19 years old in Salvador, Brazil. The carriage prevalence was 4.5% (54/1200), with no statistical difference among sex and age, although we observed a trend towards higher carriage prevalence among 11-year-old individuals. Whole genome sequence analysis revealed a high genetic diversity among the isolates, with the presence of 32 different STs, 28 (87.5%) of which were new. A total of 21/50 (42%) isolates belonged to three different clonal complexes. While none of the isolates contained nadA or fHpb alleles, we detected 21 FetA variants, 20 NhbA variants and two variants of PorB. The data provide detailed information on circulating N. lactamica isolates in adolescents in Brazil and are complementary to studies in other countries.