Detalhe da pesquisa
1.
Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy.
Bioorg Med Chem Lett;
29(20): 126640, 2019 10 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31500996
2.
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration.
JCI Insight;
9(1)2024 Jan 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37988164
3.
Identification of Nonfunctional Alternatively Spliced Isoforms of STING in Human Acute Myeloid Leukemia.
Cancer Res Commun;
4(3): 911-918, 2024 Mar 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38477596
4.
KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response.
bioRxiv;
2023 Jan 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36711647
5.
KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response.
J Immunother Cancer;
11(9)2023 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37657842
6.
Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer.
Cancer Cell;
41(11): 1972-1988.e5, 2023 11 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37922910
7.
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity.
Cancer Cell;
41(7): 1207-1221.e12, 2023 07 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37327789
8.
Longitudinal Immune Profiling Reveals Unique Myeloid and T-cell Phenotypes Associated with Spontaneous Immunoediting in a Prostate Tumor Model.
Cancer Immunol Res;
9(5): 529-541, 2021 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33637604
9.
High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege.
J Immunother Cancer;
9(8)2021 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34341132
10.
Blocking IL1 Beta Promotes Tumor Regression and Remodeling of the Myeloid Compartment in a Renal Cell Carcinoma Model: Multidimensional Analyses.
Clin Cancer Res;
27(2): 608-621, 2021 01 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33148676
11.
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion.
Nat Genet;
53(3): 332-341, 2021 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33649592
12.
Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype.
Cancer Immunol Res;
8(11): 1365-1380, 2020 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32917656
13.
TLR9 activation cooperates with T cell checkpoint blockade to regress poorly immunogenic melanoma.
J Immunother Cancer;
7(1): 323, 2019 11 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31771649
14.
Activation of 4-1BB on Liver Myeloid Cells Triggers Hepatitis via an Interleukin-27-Dependent Pathway.
Clin Cancer Res;
24(5): 1138-1151, 2018 03 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29301830
15.
Intratumoral STING Activation with T-cell Checkpoint Modulation Generates Systemic Antitumor Immunity.
Cancer Immunol Res;
5(8): 676-684, 2017 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28674082