Detalhe da pesquisa
1.
Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.
Proc Natl Acad Sci U S A;
117(47): 29595-29601, 2020 11 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33154157
2.
Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus-neutralizing activity in vaccinated mice.
Plant Biotechnol J;
19(10): 2027-2039, 2021 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34002936
3.
Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease*.
Chemistry;
27(44): 11291-11297, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34106504
4.
Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.
Proc Natl Acad Sci U S A;
114(32): 8544-8549, 2017 08 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28739903
5.
Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc Natl Acad Sci U S A;
113(32): E4630-8, 2016 08 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27462106
6.
Structural Insights into the Broad-Spectrum Antiviral Target Endoplasmic Reticulum Alpha-Glucosidase II.
Adv Exp Med Biol;
1062: 265-276, 2018.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29845539
7.
Iminosugar antivirals: the therapeutic sweet spot.
Biochem Soc Trans;
45(2): 571-582, 2017 04 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28408497
8.
Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase.
Proc Natl Acad Sci U S A;
109(3): 781-6, 2012 Jan 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22219371
9.
Non-specific accumulation of glycosphingolipids in GNE myopathy.
J Inherit Metab Dis;
37(2): 297-308, 2014 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24136589
10.
Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins.
Cell Mol Life Sci;
70(15): 2799-814, 2013 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23503623
11.
Engineering hydrophobic protein-carbohydrate interactions to fine-tune monoclonal antibodies.
J Am Chem Soc;
135(26): 9723-32, 2013 Jul 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23745692
12.
C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.
J Org Chem;
78(15): 7380-97, 2013 Aug 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23688199
13.
Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays.
Pathogens;
12(3)2023 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36986321
14.
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science;
382(6671): eabo7201, 2023 11 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37943932
15.
Restricted processing of glycans by endomannosidase in mammalian cells.
Glycobiology;
22(10): 1282-8, 2012 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22641772
16.
Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes.
Bioorg Med Chem;
20(2): 641-9, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20971647
17.
Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase.
Biochem J;
438(1): 133-42, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21585340
18.
Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells.
Antiviral Res;
199: 105269, 2022 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35227758
19.
Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release.
Antimicrob Agents Chemother;
55(3): 1036-44, 2011 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21173177
20.
Urinary glycan markers for disease.
Biochem Soc Trans;
39(1): 393-8, 2011 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21265811