RESUMO
A 67-year-old woman with acute renal insufficiency, who was on hemodialysis, developed progressive skin lesions consistent with thickening and hardening of the skin in both the back and extremities without contracture upon flexure. Her face was not affected. Laboratory evaluation was unremarkable and a skin biopsy showed an increase in collagen and interstitial mucin with no inflammatory infiltrate. These clinical features resemble a new recently reported disorder, nephrogenic fibrosing dermopathy. This disorder manifests itself as scleromyxedema-like skin lesions without associated paraproteinemia, occurring in the setting of renal disease. The incidence, prevalence and etiology of the disease are unknown and currently no effective treatment is available. This is the first case reported in Colombia.
Assuntos
Injúria Renal Aguda/complicações , Dermatopatias/etiologia , Pele/patologia , Injúria Renal Aguda/terapia , Idoso , Antígenos CD/imunologia , Antígenos CD34/imunologia , Antígenos de Diferenciação Mielomonocítica/imunologia , Biópsia , Diagnóstico Diferencial , Feminino , Fibrose , Seguimentos , Humanos , Imuno-Histoquímica , Macrófagos , Diálise Renal , Pele/metabolismo , Dermatopatias/imunologia , Dermatopatias/patologiaRESUMO
El lupus eritematoso cutáneo (LEC) es una enfermedad inflamatoria crónica, autoinmune, que tiene diversos patrones clínicos, con evolución y pronóstico variables, y que puede o no presentarse junto con una enfermedad sistémica. Es infrecuente en niños, más en los de sexo masculino. En este artículo se presentan dos niños con lupus eritematoso sistémico (LES) con diferente compromiso en la piel. Se discute la clínica y la actual clasificación del LEC infantil y se compara con las variantes del adulto.