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1.
Scand J Med Sci Sports ; 31(6): 1352-1362, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33638920

RESUMO

This study aimed to establish the association and differences in a diversity of cognitive domains according to cardiorespiratory fitness (CRF), muscular fitness (MF), and speed-agility fitness (S-AF) level in a large sample of Chilean schoolchildren. 1171 Chilean schoolchildren aged 10-14 years participated. CRF, MF, and S-AF were assessed through the ALPHA-fitness test battery. Cognition was evaluated through the NeuroCognitive Performance Test, which involved eight tests related to four main domains: cognitive flexibility (CF), working memory (WM), inhibitory control (IC), and intelligence (IN). Both global (multivariate) and individual (univariate) analyses were performed to determine the differences in cognitive functioning according to low-, middle-, and high-fitness level. The global analyses showed a significant main effect for CRF, F(16,940)  = 3.08, p ≤ .001 and MF groups, F(16,953)  = 2.30, p = .002, but not for S-AF, F(16,948)  = 1.37, p = .105. CRF shows a significant main effect in seven of eight tests, involving CF, WM, IC, and IN domains, whereas MF shows a significant main effect in five of eight tests without association with IN. SA-F shows a significant main effect only with IC. Statistical differences were found between the low- and middle/high-fitness groups but not between the middle- and high-fitness groups. At a global level, both CRF and MF seem to be associated with a higher cognitive profile in scholars; however, at an individual level, all fitness components show a favorable relationship to some cognitive domine. Then, future cognitive developing strategies should consider all fitness components, prioritizing those low-fitness schoolchildren.


Assuntos
Aptidão Cardiorrespiratória/fisiologia , Cognição/fisiologia , Inibição Psicológica , Inteligência/fisiologia , Memória de Curto Prazo/fisiologia , Força Muscular/fisiologia , Adolescente , Análise de Variância , Criança , Chile , Estudos Transversais , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Aptidão Física/fisiologia , Corrida/fisiologia
2.
Int J Mol Sci ; 21(21)2020 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-33171747

RESUMO

Liver disease encompasses pathologies as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, alcohol liver disease, hepatocellular carcinoma, viral hepatitis, and autoimmune hepatitis. Nowadays, underlying mechanisms associating gut permeability and liver disease development are not well understood, although evidence points to the involvement of intestinal microbiota and their metabolites. Animal studies have shown alterations in Toll-like receptor signaling related to the leaky gut syndrome by the action of bacterial lipopolysaccharide. In humans, modifications of the intestinal microbiota in intestinal permeability have also been related to liver disease. Some of these changes were observed in bacterial species belonging Roseburia, Streptococcus, and Rothia. Currently, numerous strategies to treat liver disease are being assessed. This review summarizes and discusses studies addressed to determine mechanisms associated with the microbiota able to alter the intestinal barrier complementing the progress and advancement of liver disease, as well as the main strategies under development to manage these pathologies. We highlight those approaches that have shown improvement in intestinal microbiota and barrier function, namely lifestyle changes (diet and physical activity) and probiotics intervention. Nevertheless, knowledge about how such modifications are beneficial is still limited and specific mechanisms involved are not clear. Thus, further in-vitro, animal, and human studies are needed.


Assuntos
Microbioma Gastrointestinal/fisiologia , Mucosa Intestinal/fisiologia , Hepatopatias/fisiopatologia , Animais , Bactérias/metabolismo , Disbiose/complicações , Humanos , Mucosa Intestinal/metabolismo , Fígado/metabolismo , Hepatopatias/microbiologia , Hepatopatias Alcoólicas/metabolismo , Microbiota/fisiologia , Hepatopatia Gordurosa não Alcoólica/metabolismo
3.
BMC Pediatr ; 19(1): 260, 2019 07 26.
Artigo em Inglês | MEDLINE | ID: mdl-31349791

RESUMO

BACKGROUND: Education and health are crucial topics for public policies as both largely determine the future wellbeing of the society. Currently, several studies recognize that physical activity (PA) benefits brain health in children. However, most of these studies have not been carried out in developing countries or lack the transference into the education field. The Cogni-Action Project is divided into two stages, a cross-sectional study and a crossover-randomized trial. The aim of the first part is to establish the associations of PA, sedentarism, and physical fitness with brain structure and function, cognitive performance and academic achievement in Chilean schoolchildren (10-13 years-old). The aim of the second part is to determinate the acute effects of three PA protocols on neuroelectric indices during a working memory and a reading task. METHODS: PA and sedentarism will be self-reported and objectively-assessed with accelerometers in a representative subsample, whilst physical fitness will be evaluated through the ALPHA fitness test battery. Brain structure and function will be assessed by magnetic resonance imaging (MRI) in a randomized subsample. Cognitive performance will be assessed through the NeuroCognitive Performance Test, and academic achievement by school grades. In the second part 32 adolescents (12-13 year-old) will be cross-over randomized to these condition (i) "Moderate-Intensity Continuous Training" (MICT), (ii) "Cooperative High-Intensity Interval Training" (C-HIIT), and (iii) Sedentary condition. Neuroelectric indices will be measures by electroencephalogram (EEG) and eye-tracking, working memory by n-back task and reading comprehension by a reading task. DISCUSSION: The main strength of this project is that, to our knowledge, this is the first study analysing the potential association of PA, sedentarism, and physical fitness on brain structure and function, cognitive performance, and academic achievement in a developing country, which presents an important sociocultural gap. For this purpose, this project will use advanced technologies in neuroimaging (MRI), electrophysiology (EEG), and eye-tracking, as well as objective and quality measurements of several physical and cognitive health outcomes. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03894241 Date of register: March 28, 2019. Retrospectively Registered.


Assuntos
Sucesso Acadêmico , Encéfalo/fisiologia , Cognição , Exercício Físico/psicologia , Aptidão Física , Acelerometria , Adolescente , Encéfalo/anatomia & histologia , Encéfalo/diagnóstico por imagem , Criança , Chile , Estudos Cross-Over , Estudos Transversais , Eletroencefalografia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Comportamento Sedentário
5.
Children (Basel) ; 11(6)2024 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-38929294

RESUMO

Basic motor skills are recognized as fundamental movements that allow children to interact with their environment and are identified as the basic structure on which more complex movements are built. OBJECTIVE: to identify the level of motor development of children from 3 to 10 years of age according to sex and age group. METHODOLOGY: We studied a sample with a total of 328 participants (girls = 170; boys = 158) at preschool (n = 154) and school levels (n = 174). The ages of the students ranged from 3 to 10 years, with a mean of 5.94 years (±2.53). TGMD2 was applied to identify motor development. RESULTS: boys and girls present low levels of physical activity, with most of them in the very poor, poor, and low-average categories (n = 182, 55.5%). Levels of motor development in locomotion, manipulation, and general development by age show significant differences (p = 0.000). However, levels of development by sex are not significant in manipulation, locomotion, and gross motor skills tests, respectively (p = 0.150, p = 0.208, and p = 0.210), and in relation to chronological age and motor development age show significant differences (p = 0.000).

6.
Children (Basel) ; 11(3)2024 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-38539372

RESUMO

Modified invasion games promote the development of real and perceived motor competence. Children with higher motor competence are more likely to participate in physical activity practice and to remain in it, both in adolescence and adulthood. (1) Background: The purpose of this study is to determine the effect of modified invasion games on the real motor competence and self-assessment of the physical condition fifth-grade students from a private school in Viña del Mar, Chile. (2) Methods: 40 girls and boys with an average age of 11.47 years (SD = 0.554) participated in this study during a 12-week intervention. The MOBAK 5-6 battery was used to assess actual motor competence, the SEMOK questionnaire was used to determine perceived motor competence, the International Fitness Scale (IFIS) self-assessment questionnaire was used to assess perceived physical fitness, and the weight/size ratio was used to determine BMI. A Friedman's nonparametric ANOVA analysis was applied to determine the effect of the intervention, in addition to an analysis of covariance (ANCOVA) to identify the influence of the covariates on motor competence. (3) Results: No statistically significant differences were established between weight, BMI, and waist circumference. There was a statistically significant difference after the intervention in the actual motor competence of object control (p = 0.005) and perceived motor competence of object control (p ≤ 0.001) (4) Conclusions: An intervention based on modified invasion games is effective for the improvement of actual and perceived motor competence of object control. It was not possible to identify a positive effect on the self-assessment of muscle strength after the intervention.

7.
J Funct Morphol Kinesiol ; 9(2)2024 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-38525758

RESUMO

An increase in the delivery and use of oxygen to the musculature in physically active subjects are determinants of improving health-related aerobic capacity. Additional health benefits, such as an increase in the muscle mass and a decrease in fat mass, principally in the legs, could be achieved with weekly global physical activity levels of more than 300 min. The objective was to compare the muscle vascular and metabolic profiles of physically very active and inactive subjects. Twenty healthy men participated in the study; ten were assigned to the physically very active group (25.5 ± 4.2 years; 72.7 ± 8.1 kg; 173.7 ± 7.6 cm) and ten to the physically inactive group (30.0 ± 7.4 years; 74.9 ± 11.8 kg; 173.0 ± 6.4 cm). The level of physical activity was determined by the Global Physical Activity Questionnaire (GPAQ). A resting vascular occlusion test (5 min of an ischemic phase and 3 min of a reperfusion phase) was used, whereas a near-field infrared spectroscopy (NIRS) device was used to evaluate the muscle oxygenation in the right vastus lateralis of the quadriceps muscle. The area under the curve of the deoxyhemoglobin (HHb) during the ischemic phase and above the curve of the tissue saturation index (TSI) during the reperfusion phase were obtained to determine muscle metabolic and vascular responses, respectively. Physically very active group showed a higher absolute HHb (3331.9 ± 995.7 vs. 6182.7 ± 1632.5 mmol/s) and lower TSI (7615.0 ± 1111.9 vs. 5420.0 ± 781.4 %/s) and relative to body weight (46.3 ± 14.6 vs. 84.4 ± 27.1 mmol/s/kg and 106.0 ± 20.6 vs. 73.6 ± 13.8 %/s/kg, respectively), muscle mass (369.9 ± 122.2 vs. 707.5 ± 225.8 mmol/kg and 829.7 ± 163.4 vs. 611.9 ± 154.2 %/s/kg) and fat mass (1760.8 ± 522.9 vs. 2981.0 ± 1239.9 mmol/s/kg and 4160.0 ± 1257.3 vs. ±2638.4 ± 994.3 %/s/kg, respectively) than physically inactive subjects. A negative correlation was observed between HHb levels and TSI (r = -0.6; p < 0.05). Physically very active men (>300 min/week) present better muscle oxidative metabolism and perfusion and perform significantly more physical activity than physically inactive subjects. Extra benefits for vascular health and muscle oxidative metabolism are achieved when a subject becomes physically very active, as recommended by the World Health Organization. In addition, a higher level of physical activity determined by GPAQ is related to better vascular function and oxidative metabolism of the main locomotor musculature, i.e., the quadriceps.

8.
Sports (Basel) ; 12(4)2024 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-38668581

RESUMO

The study aimed to calculate training intensity and load using muscle oxygen saturation (SmO2) during two differentiated physical tasks. 29 university athletes participated in a 40-m Maximal Shuttle Run Test (MST, 10 × 40-m with 30 s recovery between sprints) and a 3000-m time trial run. Distance and time were used to calculate external load (EL). Internal load indicators were calculated based on percentage of maximum heart rate (%HRMAX) and SmO2 variables: muscle oxygen extraction (∇%SmO2) and the cardio-muscle oxygen index (CMOI) was also provided by relating ∇%SmO2 ÷ %HRMAX, and the training load were calculated as the product of speed (m/min × IL) and the efficiency index [Effindex (m/min ÷ IL)]. A student t test was applied based on Bayesian factor analysis. As expected, EL differed in the 40-m MST (331 ± 22.8) vs. 3000-m trials (222 ± 56.8) [BF10 = 6.25e+6; p = <0.001]. Likewise, IL showed higher values in 40-m MST (39.20 ± 15.44) vs. 3000-m (30.51 ± 8.67) in CMOI: [BF10 = 1.70; p = 0.039]. Training load was greater in 40-m MST (85.77 ± 27.40) vs. 3000-m (15.55 ± 6.77) [(m/min × ∇%SmO2): BF10 = 12.5; p = 0.003] and 40-m MST (129.27 ± 49.44) vs. 3000-m (70.63 ± 32.98) [(m/min × CMOI): BF10 = 169.6; p = <0.001]. Also, the Effindex was higher in 40-m MST (10.19 ± 4.17) vs. 3000-m (6.06 ± 2.21) [(m/min × ∇%SmO2): BF10 = 137.03; p = <0.001] and 40-m MST (9.69 ± 4.11) vs. 3000-m (7.55 ± 1.87) [(m/min × CMOI): BF10 = 1.86; p = 0.035]. This study demonstrates calculations of training intensity and load based on SmO2 as an internal load indicator along with speed as an external load indicator during two differentiated exercises.

9.
Rev Esp Geriatr Gerontol ; 58(2): 96-103, 2023.
Artigo em Espanhol | MEDLINE | ID: mdl-37005188

RESUMO

BACKGROUND AND OBJECTIVE: In this article we sought to characterize the Long Stay Establishments for the Elderly in Chile, besides presenting the services offered in the public and private. MATERIAL AND METHODS: It is a quantitative, cross-sectional descriptive study, with secondary information source. We analyze all establishments in the country registered with the National Service of the Elderly. As of November 2015, a total of 724 establishments were registered and distributed in 169 neighborhoods throughout the country in which 16,985 adults aged 60 and over were institutionalized. RESULTS: Most of the establishments (65.9% [n=246/724]) are private, 47.5% of them (n=344/724) are located in the metropolitan region of Santiago. Of the residents' health, only 26.5% are considered functional brave, 28.3% are physically handicapped and 8.8% are mentally handicapped. Most establishments offer manual activities, physical exercises, memory classes, cultural classes and recreational or touristic tours. Proportionally of the activities offered were mostly private ones. CONCLUSIONS: In Chile, most of the establishments are private, located in the metropolitan region where there is the largest supply deficit of this type of service, with an occupancy rate of 90.7%, with 72.4% women and almost half 47.7% with some physical or psychic dependence.


Assuntos
Estudos Transversais , Idoso , Humanos , Feminino , Pessoa de Meia-Idade , Masculino , Chile
10.
J Funct Morphol Kinesiol ; 8(4)2023 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-37987485

RESUMO

This study aimed to associate body composition with fractional oxygen extraction at rest in healthy adult men. Fourteen healthy adults (26.93 ± 2.49 years) from Chile participated. Body composition was assessed with octopole bioimpedance, and resting muscle oxygenation was evaluated in the vastus lateralis quadriceps with near-infrared spectroscopy (NIRS) during a vascular occlusion test, analyzing the muscleVO2, resaturation velocity during reactive hyperemia via the muscle saturation index (%TSI), and the area above the curve of HHb (AACrep). It was observed that the total and segmented fat mass are associated with lower reoxygenation velocities during hyperemia (p = 0.008; ß = 0.678: p = 0.002; ß = 0.751), and that the total and segmented skeletal muscle mass are associated with higher reoxygenation velocities during hyperemia (p = 0.020; ß = -0.614: p = 0.027; ß = -0.587). It was also observed that the total and segmented fat mass were associated with a higher area above the curve of HHb (AACrep) during hyperemia (p = 0.007; ß = 0.692: p = 0.037; ß = 0.564), and that total and segmented skeletal muscle mass was associated with a lower area above the curve of HHb (AACrep) during hyperemia (p = 0.007; ß = -0.703: p = 0.017; ß = -0.632). We concluded that fat mass is associated with lower resaturation rates and lower resting fractional O2 extraction levels. In contrast, skeletal muscle mass is associated with higher resaturation rates and fractional O2 extraction during reactive hyperemia. The AACrep may be relevant in the evaluation of vascular adaptations to exercise and metabolic health.

11.
Front Nutr ; 9: 904831, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36386944

RESUMO

Objective: This study aims to determine the mediating role of physical fitness in the relationship between fatness indicators and academic achievement, exploring the influence of school vulnerability. Methods: A total of 1,296 Chilean adolescents (aged 10 to 14 years; 50% girls) participated in this study. The global fitness score (GFS) was obtained by adding the three main components of the ALPHA fitness test: cardiorespiratory fitness (CRF), muscular fitness (MF), and speed/agility fitness (SAF). CRF was evaluated through the 20 m shuttle run test; MF by upper and lower limb strength tests; and SAF by the 4 × 10 shuttle run test. BMIz and WHtR were evaluated as general (unspecific) and central (specific) fatness indicators. Academic achievement was established through grades in math, language, and science and their average scores. Multiple mediation analyses were performed according to two models, adjusted for sex, maturity, and schools (model 1), and in model 2, the school vulnerability index (SVI) was added. The SVI is an important proxy of socioeconomic status at the school level, and it was categorized as high-, mid-, or low-SVI. Mediation percentages were calculated, and confidence intervals (bootstrapping) were used to establish significant findings. Results: CRF, SAF, and GFS mediate the relationship between fatness indicators and academic achievement, both partially and totally (ranging from 12.7 to 59.2%). However, MF did not show any mediation effect. After controlling for SVI, CRF, and GFS, mediation changed from partial to total in the associations between math and science with WHtR. Although SAF contributed to GFS mediation, CRF seems to have the most significant mediation role for all academic achievements, regardless of SVI and the fat indicator studied. Conclusion: A higher level of general physical fitness, especially CRF, significantly mediates the detrimental influence of fatness on the academic achievement of schoolchildren. This study suggests that physical fitness plays a relevant role in academic and public health, considering the high prevalence and detrimental influence of obesity and school vulnerability in children and adolescents.

12.
Science ; 376(6595): 839-844, 2022 05 20.
Artigo em Inglês | MEDLINE | ID: mdl-35298279

RESUMO

Forest restoration is being scaled up globally to deliver critical ecosystem services and biodiversity benefits; however, there is a lack of rigorous comparison of cobenefit delivery across different restoration approaches. Through global synthesis, we used 25,950 matched data pairs from 264 studies in 53 countries to assess how delivery of climate, soil, water, and wood production services, in addition to biodiversity, compares across a range of tree plantations and native forests. Benefits of aboveground carbon storage, water provisioning, and especially soil erosion control and biodiversity are better delivered by native forests, with compositionally simpler, younger plantations in drier regions performing particularly poorly. However, plantations exhibit an advantage in wood production. These results underscore important trade-offs among environmental and production goals that policy-makers must navigate in meeting forest restoration commitments.


Assuntos
Recuperação e Remediação Ambiental , Florestas , Biodiversidade , Recuperação e Remediação Ambiental/métodos , Árvores , Água
13.
Front Public Health ; 10: 917970, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36033774

RESUMO

Objective: The aim of this study was to compare academic achievement, cognitive performance, playtime, bullying, and discrimination in adolescents according to traditional uniforms (TUs) and sports uniforms (SUs) worn at school, while simultaneously exploring the influence of the school vulnerability index. Methods: A total of 988 Chilean adolescents (52.6% boys) aged 10-14 years participated in this cross-sectional study. Academic achievement was evaluated by the average grade in maths, language, and science grades, while cognitive performance was assessed through eight cognitive tasks. TUs affecting physical activity, playtime, bullying, and discrimination were queried. Mixed model analyses were performed. Results: No differences were observed in academic achievement (TU: 5.4 ± 0.1 vs. SU: 5.5 ± 0.2, p = 0.785) or in cognitive performance (TU: 99.6 ± 0.8 vs. SU: 98.9 ± 1.8, p= 0.754) according to the school uniformtype. Moreover, 64.1 % of participants declared that wearing TU affects their physical activity (traditional uniforms: + 8 min and sports uniforms: + 20 min), and those who believed so spent more time playing than those who answered negatively (14.5 min, p = 0.012). Finally, adolescents wearing SU displayed a lower feeling of bullying and discrimination; this finding depended mainly on the school's vulnerability. Conclusion: It is concluded that wearing TU does not show an educational advantage at an academic and cognitive level that justifies its obligation. In addition, it could be suggested that schools consider adolescents' opinions in adopting a more comfortable uniform, such as the SU. This feasible and low-cost measure would help to increase adolescents' physical activity during the school day, and, contrary to belief, it would not be related to increased feelings of bullying and discrimination.


Assuntos
Sucesso Acadêmico , Bullying , Logro , Adolescente , Cognição , Estudos Transversais , Feminino , Humanos , Masculino
14.
EFORT Open Rev ; 6(12): 1193-1202, 2021 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-35839102

RESUMO

Adequate sagittal balance (SB) is essential to maintain an upright, efficient, and painless posture. It has been shown that sagittal profile alterations affect quality of life of patients with a similar or even greater impact than chronic disease. Evaluation of the SB has gained much relevance in recent years, with recognition of its importance in the evaluation of spinal pathology. This review summarizes the basic principles of SB, aiming to obtain a practical, simple and understandable evaluation of the sagittal profile of a patient. SB is a dynamic process that involves a varying degree of energy expenditure. Distinguishing between a balanced, compensated imbalance or decompensated imbalanced patient, is relevant to diagnosis and therapeutic decision-making.

15.
Ecancermedicalscience ; 15: 1244, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34267800

RESUMO

Gastric cancer (GC) is a leading cause of cancer death in Chile. Although recommended in international guidelines since 2006, perioperative chemotherapy was not available to patients in the public health system in Chile until 2016. We conducted an observational study to assess the feasibility of this strategy in public hospitals in Chile (Observational Study of Perioperative Chemotherapy in Locally Advanced Gastric Cancer - PRECISO). Patients with locally advanced, operable GC were offered to receive preoperative chemotherapy with Epirubicin + Cisplatin + Capecitabine (ECX) for three cycles followed by curative surgery. Staging included abdominal CT scan and laparoscopy if peritoneal carcinomatosis was suspected. Postoperative ECX for three cycles was recommended. Between August 2010 and March 2013, 110 patients were screened and 61 enrolled. Median age was 62 years (23-76 years) and most patients had good performance status at baseline (Eastern Cooperative Oncology Group performance status score (ECOG) 0: 42, ECOG 1: 19). Tumour site was proximal in 32 (52%) and medial and distal in 29 (48%) patients. All but four patients (n = 57, 93%) completed three cycles of preoperative chemotherapy. Fifty-six patients were operated and 54 (89%) had a curative resection. Thirty-three patients (54%) had pT0-2, and 18 (30%) had pN0 tumours, with two patients achieving a complete response. As of 20 December 2020, 39 patients died, 32 due to GC, one within 30 days of surgery, two due to intestinal obstruction at 5 and 3 months after surgery and four due to other causes. Five-year survival rate was 38%. We conclude that perioperative chemotherapy is feasible in public hospitals in Chile and should be offered to patients with locally advanced GC.

16.
Biomedicines ; 9(2)2021 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-33546191

RESUMO

Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of chronic liver illness associated with obesity and metabolic disorders, such as hypertension, dyslipidemia, or type 2 diabetes mellitus. A more severe type of NAFLD, non-alcoholic steatohepatitis (NASH), is considered an ongoing global health threat and dramatically increases the risks of cirrhosis, liver failure, and hepatocellular carcinoma. Several reports have demonstrated that liver steatosis is associated with the elevation of certain clinical and biochemical markers but with low predictive potential. In addition, current imaging methods are inaccurate and inadequate for quantification of liver steatosis and do not distinguish clearly between the microvesicular and the macrovesicular types. On the other hand, an unhealthy status usually presents an altered gut microbiota, associated with the loss of its functions. Indeed, NAFLD pathophysiology has been linked to lower microbial diversity and a weakened intestinal barrier, exposing the host to bacterial components and stimulating pathways of immune defense and inflammation via toll-like receptor signaling. Moreover, this activation of inflammation in hepatocytes induces progression from simple steatosis to NASH. In the present review, we aim to: (a) summarize studies on both human and animals addressed to determine the impact of alterations in gut microbiota in NASH; (b) evaluate the potential role of such alterations as biomarkers for prognosis and diagnosis of this disorder; and (c) discuss the involvement of microbiota in the current treatment for NAFLD/NASH (i.e., bariatric surgery, physical exercise and lifestyle, diet, probiotics and prebiotics, and fecal microbiota transplantation).

17.
Nutrients ; 13(11)2021 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-34836254

RESUMO

Physical activity, exercise, or physical fitness are being studied as helpful nonpharmacological therapies to reduce signaling pathways related to inflammation. Studies describing changes in intestinal microbiota have stated that physical activity could increase the microbial variance and enhance the ratio of Firmicutes/Bacteroidetes, and both actions could neutralize the obesity progression and diminish body weight. The aim of this review is to provide an overview of the literature describing the relationship between physical activity profiles and gut microbiota and in obesity and some associated comorbidities. Promoting physical activity could support as a treatment to maintain the gut microbiota composition or to restore the balance toward an improvement of dysbiosis in obesity; however, these mechanisms need to be studied in more detail. The opportunity to control the microbiota by physical activity to improve health results and decrease obesity and related comorbidities is very attractive. Nevertheless, several incompletely answered questions need to be addressed before this strategy can be implemented.


Assuntos
Exercício Físico , Microbioma Gastrointestinal , Obesidade , Bacteroidetes , Peso Corporal , Disbiose , Firmicutes , Humanos , Inflamação , Doenças não Transmissíveis , Obesidade/metabolismo
18.
Artigo em Inglês | MEDLINE | ID: mdl-32290376

RESUMO

The aims of this cross-sectional study were (i) to determine the association of educational level attained with cognitive impairment and (ii) to investigate the mediating effect of different self-report physical activity (PA) patterns in a large sample of older Chileans. A sample of 1571 older adults from the National Chilean Survey (2016-2017) was included. The educational level attained, PA levels, mode of commuting, sedentary time, and leisure-time PA were self-reported through validated questionnaires. Cognitive impairment was determined by Mini-Mental State Examination (modified version). Association between educational level attained and cognitive impairment was examined using logistic regression models. Counterfactual mediation models were used to test the mediating effect of self-reported PA patterns. A lower educational level was consistently associated with higher odds of cognitive impairment (OR range 2.846 to 2.266, all p < 0.001), while leisure-time PA was the only PA pattern that partially mediated this association (proportion mediated 8.0%). In conclusion, leisure-time PA was the solely PA pattern that partially mediated the association between the educational level and cognitive impairment. The rest self-reported PA patterns did not modify this association.


Assuntos
Disfunção Cognitiva , Comportamento Sedentário , Idoso , Chile , Estudos Transversais , Exercício Físico , Feminino , Humanos , Masculino , Autorrelato , Inquéritos e Questionários
19.
Int. j. morphol ; 42(2)abr. 2024.
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1558121

RESUMO

SUMMARY: Trail running (TR), an extreme endurance sport, presents unique challenges due to the variety of terrain and distances, where physiological capacity and body composition have been considered better predictors of performance. This longitudinal case study examines the impact of training intensity distribution (TID) on an elite trail runner's physiological profile and performance over four years. Two TID models were implemented: polarized (POL) and pyramidal (PYR). Physiological assessments included maximal oxygen consumption (VO2max), lactate thresholds (LT1 and LT2), and anthropometric characteristics. The training was classified according to the 3-zone intensity model (zone 1: below the first lactate threshold; zone 2: between the first and second lactate threshold; zone 3: above the second lactate threshold). During the four years, the average TID distribution was 75 % zone 1, 18 % zone 2, and 7 % zone 3. Physiological capacity increased by 7.14 % (14 to 15 km/h) for velocity at LT1 (vLT1) and 8.13 % (16 to 17.3 km/h) for velocity at LT2 (vLT2). The most significant increases were observed during the second year when the percentage of training time in zone 1 was lower (65 %) and in zone 2 greater (30 %) than those reported in other years. Consequently, vLT1 and vLT2 increased by 3.5 % (from 14.1 to 14.6 km/h) and 3.6 % (from 16.5 to 17.1 km/h), respectively. In conclusion, this case study revealed that emphasizing training in zone 2 (moderate intensity) and increasing the training load significantly improved performance at lactate thresholds. Despite modifying body composition, no influence on improving endurance performance was observed. These findings underscore the importance of TID in elite trail runners and highlight the potential to optimize physiological adaptations and performance outcomes.


Trail running (TR), un deporte de resistencia extrema, presenta desafíos únicos debido a la variedad de terrenos y distancias, donde la capacidad fisiológica y la composición corporal se han considerado mejores predictores del rendimiento. Este estudio de caso longitudinal examina el impacto de la distribución de la intensidad del entrenamiento (TID) en el perfil fisiológico y el rendimiento de un corredor de montaña de élite durante cuatro años. Se implementaron dos modelos TID: polarizado (POL) y piramidal (PYR). Las evaluaciones fisiológicas incluyeron el consumo máximo de oxígeno (VO2max), los umbrales de lactato (LT1 y LT2) y las características antropométricas. El entrenamiento se clasificó según el modelo de intensidad de 3 zonas (zona 1: por debajo del primer umbral de lactato; zona 2: entre el primer y segundo umbral de lactato; zona 3: por encima del segundo umbral de lactato). Durante los cuatro años, la distribución TID promedio fue 75 % zona 1, 18 % zona 2 y 7 % zona 3. La capacidad fisiológica aumentó un 7,14 % (14 a 15 km/h) para la velocidad en LT1 (vLT1) y un 8,13 % (16 a 17,3 km/h) para velocidad en LT2 (vLT2). Los incrementos más significativos se observaron durante el segundo año cuando el porcentaje de tiempo de entrenamiento en la zona 1 fue menor (65 %) y en la zona 2 mayor (30 %) que los reportados en otros años. En consecuencia, vLT1 y vLT2 aumentaron un 3,5 % (de 14,1 a 14,6 km/h) y un 3,6 % (de 16,5 a 17,1 km/h), respectivamente. En conclusión, este estudio reveló que enfatizar el entrenamiento en la zona 2 (intensidad moderada) y aumentar la carga de entrenamiento mejoró significativamente el rendimiento en los umbrales de lactato. A pesar de modificar la composición corporal, no se observó influencia en la mejora del rendimiento de resistencia. Estos hallazgos subrayan la importancia del TID en los corredores de trail de élite y resaltan el potencial para optimizar las adaptaciones fisiológicas y los resultados de rendimiento.

20.
Int. j. morphol ; 42(2)abr. 2024.
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1558148

RESUMO

El Tang Soo Do es un arte marcial versátil que destaca por el uso de la cadera para sus gestos técnicos. El karate es una de las artes marciales más atractivas alrededor del mundo. Tanto karate como Tang Soo Do comparten un estilo firme en sus técnicas y combate. Sin embargo, algunas de las formas en Tang Soo Do poseen un estilo suave similar al kung fu y al tai chi. Por ello, es interesante describir y comparar las capacidades físicas y la composición corporal de los practicantes de Tang Soo Do y karate a nivel recreativo. Para ello, se realizó una búsqueda en Medline® y Web of Science® durante enero de 2021. Se escogieron 10 estudios, organizando sus datos según composición corporal, fuerza muscular, resistencia muscular, flexibilidad y VO2max. Se encontraron 2 estudios en practicantes recreativos de Tang Soo Do y 8 en karate a nivel mundial, por lo que no existen suficientes estudios que permitan describir y comparar adecuadamente las capacidades físicas y la composición corporal entre sus practicantes a nivel recreativo; sin embargo, los resultados encontrados indican que es importante realizar más investigaciones que midan estas variables, con la finalidad de considerar en base a la evidencia alTang Soo Do como una importante opción para el bienestar físico y mental de sus practicantes. Las investigaciones futuras pueden evaluar estos datos en distintos grupos etarios, localización, tiempo de entrenamiento o tipos de competiciones según formas, combate o mixto. Además, se pueden realizar estudios comparativos en los practicantes de Tang Soo Do que permita a este arte marcial ser desde la evidencia una importante opción de práctica en colegios y universidades, así como un estilo de vida para sus practicantes.


SUMMARY: Tang Soo Do is a versatile martial art that stands out for the use of the hip for its technical gestures. Karate is one of the most attractive martial arts around the world. Both karate and Tang Soo Do share a firm style in their techniques and combat. However, some of the forms in Tang Soo Do possess a gentle style similar to Kung Fu and Tai Chi. Therefore, it is interesting to describe and compare the physical abilities and body composition of recreational Tang Soo Do and karate practitioners. A search was carried out in Medline® and Web of Science® during January 2021. Following the search 10 studies were chosen, organizing their data according to body composition, muscular strength, muscular resistance, flexibility and VO2max. Two studies were found on recreational Tang Soo Do practitioners and eight on karate worldwide, hence, there are not enough studies to adequately describe and compare physical abilities and body composition among recreational practitioners; However, the results found, indicate that it is important to conduct further research to measures these variables, in order to consider Tang Soo Do as an important option for the physical and mental well-being of its practitioners. Future research can evaluate these data can be evaluated in different age groups, location, training time or types of competitions according to forms, combat or mixed. In addition, comparative studies can be carried out on Tang Soo Do practitioners that allow this martial art to become an important option for practice in schools and universities, as well as a lifestyle for its practitioners.

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