Detalhe da pesquisa
1.
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.
Cell;
172(3): 409-422.e21, 2018 01 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29290465
2.
Thioredoxin Reductase Inhibition for Cancer Therapy.
Annu Rev Pharmacol Toxicol;
62: 177-196, 2022 01 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34449246
3.
Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology.
J Am Chem Soc;
146(8): 5204-5214, 2024 Feb 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38358897
4.
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.
Physiol Rev;
96(1): 307-64, 2016 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26681794
5.
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
Proc Natl Acad Sci U S A;
116(23): 11408-11417, 2019 06 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31097586
6.
Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif.
J Am Chem Soc;
143(23): 8791-8803, 2021 06 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34061528
7.
Effects of Mammalian Thioredoxin Reductase Inhibitors.
Handb Exp Pharmacol;
264: 289-309, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32767140
8.
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades.
J Biol Chem;
294(33): 12330-12338, 2019 08 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31197039
9.
Identification and targeting of selective vulnerability rendered by tamoxifen resistance.
Breast Cancer Res;
22(1): 80, 2020 07 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32727562
10.
Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase.
Inorg Chem;
59(5): 2711-2718, 2020 Mar 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32049511
11.
Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation.
J Biol Chem;
292(13): 5476-5487, 2017 03 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28193838
12.
Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure.
J Biol Chem;
292(35): 14371-14380, 2017 09 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28684416
13.
Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress.
Biochim Biophys Acta Gen Subj;
1861(5 Pt A): 1177-1189, 2017 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28286015
14.
Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.
Proc Natl Acad Sci U S A;
111(19): 6964-9, 2014 May 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24778250
15.
Redox active motifs in selenoproteins.
Proc Natl Acad Sci U S A;
111(19): 6976-81, 2014 May 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24769567
16.
Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells.
Mol Pharm;
13(6): 2010-25, 2016 06 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27093577
17.
Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-ß receptor tyrosine kinase signaling.
Proc Natl Acad Sci U S A;
110(33): 13398-403, 2013 Aug 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23901112
18.
Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury.
Biochim Biophys Acta;
1840(7): 2105-11, 2014 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24608031
19.
Wobble decoding by the Escherichia coli selenocysteine insertion machinery.
Nucleic Acids Res;
41(21): 9800-11, 2013 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23982514
20.
The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.
Mol Pharmacol;
85(6): 932-45, 2014 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24714215