Detalhe da pesquisa
1.
Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation.
Bioconjug Chem;
34(9): 1679-1687, 2023 09 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37657082
2.
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Cell Death Dis;
15(6): 408, 2024 Jun 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38862470
3.
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
ACS Chem Biol;
19(2): 266-279, 2024 02 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38291964
4.
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.
J Med Chem;
67(1): 674-690, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38126712
5.
Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.
J Med Chem;
67(5): 3813-3842, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38422480
6.
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.
J Med Chem;
67(11): 8609-8629, 2024 Jun 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38780468
7.
Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily.
Eur J Med Chem;
254: 115347, 2023 Jun 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37094449
8.
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog.
Cell Death Dis;
13(3): 214, 2022 03 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35256607
9.
Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C.
ACS Pharmacol Transl Sci;
5(11): 1169-1180, 2022 Nov 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36407959
10.
Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study.
Curr Pharm Des;
26(8): 838-866, 2020.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32039675
11.
The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies.
Cancers (Basel);
12(1)2019 Dec 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31878315