Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Revista
Intervalo de ano de publicação
1.
Cell ; 163(2): 456-92, 2015 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-26451489

RESUMO

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm(3) containing ~31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ~8 million connections with ~37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies. PAPERCLIP: VIDEO ABSTRACT.


Assuntos
Simulação por Computador , Modelos Neurológicos , Neocórtex/citologia , Neurônios/classificação , Neurônios/citologia , Córtex Somatossensorial/citologia , Algoritmos , Animais , Membro Posterior/inervação , Masculino , Neocórtex/fisiologia , Rede Nervosa , Neurônios/fisiologia , Ratos , Ratos Wistar , Córtex Somatossensorial/fisiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA