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1.
J Drugs Dermatol ; 23(3): e86-e90, 2024 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-38443118

RESUMO

Hair loss, a pervasive and often distressing condition, affects a substantial number of individuals globally. Although conventional treatments such as hair transplantation, topicals, oral medications, and injectables exist, they have limitations, including the necessity for repeated treatments, potential adverse effects, and cost barriers. Exosome therapy, an innovative and burgeoning option within regenerative medicine, offers a novel approach to hair loss treatment. Exosomes are small vesicles that are produced from the membranes of late-endosomes and secreted by cells, playing a crucial role in intercellular communication. Research on humans is limited,1-4 and animal studies have shown that exosomes derived from various cell types can stimulate hair growth, resulting in increased research and development of exosome therapy for hair loss.5 Establishing a uniform reporting method for exosome therapy is vital as research in this area continues to expand. A standardized approach to research reporting and results is essential for comprehending the underlying mechanisms, safety, and efficacy of exosome therapy. This article provides an in-depth analysis of the current state of exosome therapy for hair loss, including potential advantages, and limitations, as well as directions for future research. J Drugs Dermatol. 2024;23(3)    doi:10.36849/JDD.7603.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Exossomos , Humanos , Animais , Alopecia/terapia , Prática Clínica Baseada em Evidências , Transplante de Pele
2.
J Am Acad Dermatol ; 89(2S): S20-S28, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37591561

RESUMO

This article discusses drug-induced hair loss, which can occur with many drugs including cytotoxic agents, biologics, and immunomodulating agents, among others. It outlines the diagnosis and management of drug-induced alopecia, with a focus on recently implicated drugs.


Assuntos
Alopecia , Produtos Biológicos , Humanos , Alopecia/induzido quimicamente , Alopecia/diagnóstico , Produtos Biológicos/efeitos adversos , Citotoxinas
3.
Dermatol Surg ; 49(9): 851-854, 2023 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-37387642

RESUMO

BACKGROUND: Mesotherapy, a technique of transdermal microinjections of specific preparations, is increasingly used in fields such as dermatology and specifically for alopecia treatment. Its popularity stems from its ability to deliver drugs in a targeted manner while minimizing systemic side effects. OBJECTIVE: To assess and review current knowledge regarding the use of mesotherapy to deliver alopecia medications and highlight future directions for research. MATERIALS AND METHODS: The authors used research databases including PubMed and Google Scholar to identify current literature on mesotherapy and alopecia. The following search terms were used among other terms: "Mesotherapy" or "Intradermal" AND "Alopecia". RESULTS: Recent studies are promising for the intradermal delivery of dutasteride and minoxidil in the treatment of androgenetic alopecia. CONCLUSION: Although limitations exist with dutasteride and minoxidil therapies, further research regarding the preparation, delivery, and maintenance of these drugs is warranted as mesotherapy could establish this technique as a safe, effective, and viable treatment option for androgenetic alopecia.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Mesoterapia , Humanos , Dutasterida/uso terapêutico , Minoxidil/uso terapêutico , Alopecia/tratamento farmacológico , Resultado do Tratamento
14.
Clin Cosmet Investig Dermatol ; 16: 803-820, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37025396

RESUMO

Alopecia areata is an autoimmune hair loss disorder with variations in distribution, duration, and severity. The disease is chronic and often follows an unpredictable course, frequently leading to stress and anxiety for those who suffer from it. Throughout the years more knowledge has been gained regarding pathogenesis, diagnostic tools, impact on quality of life, as well as treatment strategies for alopecia areata. However, challenges in treating and alleviating the burden of disease remain. In this article, we discuss updates regarding the pathogenesis and treatment of alopecia areata and highlight unmet needs of the condition, including a review of limitations of current treatments, accessibility to management strategies, and the need for disease awareness and advocacy.

15.
JBJS Case Connect ; 12(1)2022 01 12.
Artigo em Inglês | MEDLINE | ID: mdl-35020634

RESUMO

CASE: We present a 36-year-old man who sustained a traumatic C5-6 unilateral facet dislocation without neurological deficit. The patient was treated with anterior diskectomy and fusion using a stand-alone interbody cage. CONCLUSION: Current treatment of cervical facet dislocations (CFDs) in patients undergoing an anterior cervical diskectomy and fusion commonly makes use of plates with screw fixation and interbody grafts or cages to achieve spinal fusion after the diskectomy is performed. This report documents the successful treatment of a CFD with a stand-alone interbody cage.


Assuntos
Doenças da Coluna Vertebral , Fusão Vertebral , Adulto , Fenômenos Biomecânicos , Parafusos Ósseos , Discotomia , Humanos , Masculino
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