Detalhe da pesquisa
1.
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell;
172(1-2): 55-67.e15, 2018 01 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29307491
2.
Cognitive-Enhancing Effects of Acetylcholine Receptor Agonists in Group-Housed Cynomolgus Monkeys Who Drink Ethanol.
J Pharmacol Exp Ther;
389(3): 258-267, 2024 May 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38135508
3.
α-[Amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile; Configurational equilibria in solution.
Bioorg Chem;
113: 104955, 2021 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34034134
4.
Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain.
J Neurosci;
39(21): 4162-4178, 2019 05 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30862664
5.
Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives.
Mol Pharmacol;
98(4): 328-342, 2020 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32690626
6.
Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats.
Int J Neuropsychopharmacol;
22(11): 735-745, 2019 11 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31613314
7.
Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism.
J Neurosci;
37(32): 7656-7668, 2017 08 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28674176
8.
Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats.
J Pharmacol Exp Ther;
365(2): 346-353, 2018 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29535156
9.
Structure of the human κ-opioid receptor in complex with JDTic.
Nature;
485(7398): 327-32, 2012 Mar 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22437504
10.
Synthesis of Enantiopure PZM21, A Novel Biased Agonist of the Mu-Opioid Receptor.
European J Org Chem;
2018(29): 4006-4012, 2018 Aug 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32831629
11.
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model.
Nicotine Tob Res;
19(4): 460-468, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27639096
12.
Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse.
Alcohol Clin Exp Res;
40(1): 62-72, 2016 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26727524
13.
Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists.
J Org Chem;
81(21): 10383-10391, 2016 11 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27462910
14.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres.
Bioorg Med Chem;
24(16): 3842-8, 2016 08 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27364611
15.
Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor.
Mol Pharmacol;
88(3): 502-11, 2015 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26134494
16.
Effects of nicotinic acetylcholine receptor agonists in assays of acute pain-stimulated and pain-depressed behaviors in rats.
J Pharmacol Exp Ther;
355(2): 341-50, 2015 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26359313
17.
Effects of acute and chronic social defeat stress are differentially mediated by the dynorphin/kappa-opioid receptor system.
Behav Pharmacol;
26(7 Spec No): 654-63, 2015 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26110224
18.
Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3'-(substituted pyridinyl)-deschloroepibatidine analogs.
Bioorg Med Chem;
23(17): 5693-701, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26233800
19.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents.
Bioorg Med Chem;
23(19): 6379-88, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26342544
20.
Simple radiometric method for accurately quantitating epitope densities of hapten-protein conjugates with sulfhydryl linkages.
Bioconjug Chem;
25(12): 2112-5, 2014 Dec 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25426820