WHEN TOPHACEOUS GOUT INVOLVES MULTIPLE ORGANS: CHALLENGES AND SOLUTIONS.

Uncontrolled chronic gout can lead to deposition of monosodium urate crystals, better known as tophi. Such depositions can involve several organ systems, including unusual locations such as the vertebrae. Nevertheless, certain complications, such as hypercalcemia, can arise because of tophi. Despite an aggressive intervention, hypercalcemia might not resolve spontaneously, as long as an ongoing inflammatory process secondary to gouty tophi is taking place. Herein, we present the case of a 62-year-old man with a long history of gouty tophi who presented for back pain and was found to have spinal cord involvement with PTH-independent hypercalcemia which only resolved with pegloticase therapy.

Accelerating orthodontic tooth movement: A new, minimally-invasive corticotomy technique using a 3D-printed surgical template.

BACKGROUND: A reduction in orthodontic treatment time can be attained using corticotomies. The aggressive nature of corticotomy due to the elevation of muco-periosteal flaps and to the duration of the surgery raised reluctance for its employ among patients and dental community. This study aims to provide detailed information on the design and manufacture of a 3D-printed CAD-CAM (computer-aided design and computer-aided manufacturing) surgical guide which can aid the clinician in achieving a minimally-invasive, flapless corticotomy. MATERIAL AND METHODS: An impression of dental arches was created; the models were digitally-acquired using a 3D scanner and saved as STereoLithography ( STL ) files. The patient underwent cone beam computed tomography (CBCT): images of jaws and teeth were transformed into 3D models and saved as an STL file. An acrylic template with the design of a surgical guide was manufactured and scanned. The STLs of jaws, scanned casts, and acrylic templates were matched. 3D modeling software allowed the view of the 3D models from different perspectives and planes with perfect rendering. The 3D model of the acrylic template was transformed into a surgical guide with slots designed to guide, at first, a scalpel blade and then a piezoelectric cutting insert. The 3D STL model of the surgical guide was printed. RESULTS: This procedure allowed the manufacturing of a 3D-printed CAD/CAM surgical guide, which overcomes the disadvantages of the corticotomy, removing the need for flap elevation. No discomfort, early surgical complications or unexpected events were observed. CONCLUSIONS: The effectiveness of this minimally-invasive surgical technique can offer the clinician a valid alternative to other methods currently in use.

The mandibular permanent second molars and their risk of impaction: a retrospective study.

AIM: The aim of this retrospective study is promote a better understanding of the impaction of teeth 37 and 47 by means of clinical and statistical data from the point of view of early interceptive treatment. STUDY DESIGN: 478 patients of the Orthodontic School of "La Sapienza" University of Rome (Italy) were studied to assess the eruption of teeth 37 and 47 on at least two good-quality panorex using angular measurements and Nolla's index from January 2008 to December 2013. Data were analysed using ANOVA and Tukey HSD test (P < 0.05). RESULTS: The data obtained on the possible correlations between the examined teeth and the four reference angles show that at t0, the angular variation of teeth 36 or 46 is constant when the teeth are at the end of their eruptive process, while for teeth 37 and 47, this variation is always constant. At t0, the first and the second molars of both quadrants, during eruption showed a similar behaviour. At t1, the four teeth examined in the patients sample showed a model of development analogous to that exhibited at t0. STATISTICS: a constant variation (t0-t1) is present among the differences in the development of the 36 and the two angular values, while difference in development of the 37 and that of the angular value is constant only in relationship to the difference in development of the mandibular first molar of the same quadrant. The variations between the difference in development of the 47 and in angular value (t0-t1) are constant only when related to the developing 46. The analytic variance of gradience (vargrad) data confirm peculiar behaviour of the first one, according to both mandibular molars, during their eruptive development. CONCLUSIONS: Adoption of universally recognised radiographic predictive methods allows assessment of the case and allows the specialist to plan a suitable treatment to prevent or intercept the molar impaction, with a perspective of a less invasive and shorter therapy. Although rare, impaction of teeth 37 and 47 often requires a complex, multidisciplinary approach.

High resolution 3-T MR imaging in the evaluation of the facial nerve course.

OBJECTIVES: To assess the value of 3-Tesla (3-T) MR imaging (MRI) in the evaluation of the course of the intracranial and extra-cranial tracts of the facial nerve. PATIENTS AND METHODS: 83 patients were studied by MRI in order to detect the course of facial nerve; a total of 166 facial nerves were examined. T2-weighted 3D Fast imaging employing steady-state acquisition (FIESTA) and T1-weighted Fast spoiled gradient recalled echo (fast SPRG) sequences were used. Two radiologists (reader A and B), independently, evaluated the course of the tracts of the facial nerve according to a qualitative scale (excellent, good, fair, poor). The Intraclass Correlation Coefficient (ICC) and Pearson correlation coefficient were used to assess the intra-observer and interobserver variability in the nerve course evaluation. RESULTS: Reader A evaluated 35 facial nerves as excellent, 94 as good, 33 as fair and 4 as poor. Reader B rated 31 facial nerves excellent, 89 good, 43 fair and 3 poor. The intraobserver variability was ICC = 0.919 in reader A and ICC = 0.842 in reader B. The interobserver variability (Pearson correlation coefficient) was 0.713 (p ≤ 0.01). CONCLUSIONS: According to the preliminary results of our study the use of 3-T MRI with FIESTA and fast SPGR sequences may allow the study of the course of the facial nerve and its branches. The knowledge of the course and of the anatomic relationships of these nerve bundles with surrounding structures, as well as of the anatomical variants, provide useful informations for a prompt neurosurgery and maxillofacial surgical planning.

The impact of osteotomy technique for corticotomy-assisted orthodontic treatment (CAOT) on oral health-related quality of life.

BACKGROUND: Corticotomy in accelerating orthodontic tooth movement, also defined as corticotomy-assisted orthodontic treatment (CAOT), is a promising technique that recently had many applications in orthodontics. AIM: The purpose of this study was to compare the use of piezoelectric surgery and conventional rotatory osteotomy technique for CAOT, determining the duration of surgery and oral health-related quality of life (OHRQoL). PATIENTS AND METHODS: CAOT was performed in a sample of subjects, randomly choosing piezoelectric surgery (PS Group) or conventional rotary osteotomy technique (RT Group). The duration of surgery was recorded and the oral health-related quality of life evaluated using the short form Oral Health Impact Profile (OHIP-14) preoperatively, 3 and 7 days after surgery. t-test and Cronbach's alpha were used for statistical analysis. RESULTS: 12 patients (mean age 14; range: 13-17) were enrolled. The time needed to complete the osteotomy cuts was greater (p = 0.1) for the piezoelectric surgery group (mean 34.3 minutes; range 35.3-32.6) than for the rotator group(mean 28.2 minutes; range 27.1-29.2). Oral health-related quality of life deteriorated from baseline (OHIP-14 mean: 6.33) to first follow-up, 3 day after surgery, in both groups (PS Group: 22.67 OHIP-14; RT Group: 21.33 OHIP-14). At 7 days follow-up there was a nearly complete recovery of the original OHIP-14 values , even faster with the conventional rotary osteotomy technique; however, no statistically significant differences were recorded between the two methods (p = 0.35). Cronbach's alpha values indicated an excellent internal consistency reliability. CONCLUSIONS: In clinical decision-making regarding the use of corticotomy-assisted orthodontic treatment, it should be aware of the expected decrease in oral health-related quality of life both using piezoelectric surgery or rotary osteotomy technique. In addition, the piezoelectric osteotomy requires a longer surgical time.

The use of high resolution magnetic resonance on 3.0-T system in the diagnosis and surgical planning of intraosseous lesions of the jaws: preliminary results of a retrospective study.

BACKGROUND: The pre-operative evaluation in oral and maxillofacial surgery is currently performed by computerized tomography (CT). However in some case the information of the traditional imaging methods are not enough in the diagnosis and surgical planning. The efficacy of these imaging methods in the evaluation of soft tissues is lower than magnetic resonance imaging (MRI). AIM: The aim of the study was to show the use of MRI in the evaluation of relation between intraosseous lesions of the jaws and anatomical structures, when it was difficult using the traditional radiographic methods, and to evaluate the usefulness of MRI to depict the morphostructural characterization of the lesions and infiltration of the soft tissues. MATERIALS AND METHODS: 10 patients with a lesion of jaw were selected. All the patients underwent panoramic radiography (OPT), CT and MRI. The images were examined by dental and maxillofacial radiology who compared the different imaging methods to analyze the morphological and structural characteristics of the lesion and assessed the relationship between the lesion and the anatomical structures. RESULTS: Magnetic resonance imaging provided more detailed spatial and structural information than other imaging methods. CONCLUSIONS: MRI allowed us to characterize the intraosseous lesions of the jaws and to plan the surgery, resulting in a lower risk of anatomic structures surgical injury.

The accuracy of CBCT in measuring jaws bone density.

BACKGROUND: The cone-beam computerized tomography (CBCT) has become widely used for oral and maxillofacial imaging, providing a good spatial resolution, gray density range, and contrast, as well as a good pixel/noise ratio. In the CBCT the dimensional accuracy is also comparable with Computer Tomography (CT), but in contrast to the CT, the gray density values of the CBCT images (voxel value [VV]) are not absolute. AIM: The aim of the study was to evaluate if there is a statistically significant difference in bone density values, defined as gray density values (VV), using two different CBCT exposure radiation (8 mAs or 15 mAs). MATERIALS AND METHODS: 10 dry mandibles were CBCT scanned using two different exposure radiation (8 mAs or 15 mAs). Using software and a radiographic template, the CBCT-scan images were overlapped and two datasets were created, each one giving the respective gray values (VV), of the same area with the same spatial coordinates. The quantified gray density values of the planned volume were measured and expressed as VV in two different exposure radiation scans Groups (Group A: 8 mAs; Group B: 15 mAs). For the statistical analysis, t-test was used. RESULTS: The differences between the CBCT gray density values (VV) of the Groups (Group A: 8 mAs; Group B: 15 mAs) were statistically significant (p <= .05). CONCLUSIONS: This study demonstrated that the use of a CBCT to evaluate the bone density of jaws is not useful when the values are taken as absolute values. In spite of the lower radiation dose and costs of CBCT, this new technique does not allow an accurate assessment of bone density.

The influence of smoking and surgical technique on the accuracy of mucosa-supported stereolithographic surgical guide in complete edentulous upper jaws.

BACKGROUND: The accuracy of a stereolithographic surgical guide depends on several variables that can affect at any time from the software-planning stage to the surgical field. AIM: The purpose of this study was to evaluate the accuracy of implants inserted using a single mucosa-supported stereolithographic surgical guide determining also the influence of surgical technique (fixed and not-fixed) and smoking on the deviation parameters. MATERIALS AND METHODS: 11 patients, totally edentate in the upper arch and needed an implant-prosthetic rehabilitation, were selected. 95 implants were planned and inserted. The pre- and post-operative CT images were compared using software. RESULTS: Global, coronal (Mean: 1.65; Range: 3.00-0.13; SD:0.56) and apical (Mean: 2.15; Range: 4.23-0.34; SD:0.81), and angular (Mean: 4.62; Range: 15.25-0.28; SD: 2.74) deviation values were determined. The mean values of mucosa thickness in smokers and nonsmokers patients were 4.53 mm and 3.42 mm respectively (p < .05). The accuracy data showed a better result for the angular deviation when the surgical template was fixed (p = .002) and a better global apical deviation in the nonsmokers (p <. 05). CONCLUSIONS: It is essential, especially in smoker patients, to respect a minimum safety distance of 3 mm from limiting anatomic structures.

[Phlegmons of the neck: our experience with 7 cases]. / Flemmoni del collo: nostra esperienza su 7 casi clinici.

Phlegmons of the neck originate from infectious diseases of head and neck. Odontogeneous inflammation of the oral cavity is most frquently primary lesion, followed by sinusitis, otitis, as well as radiation therapy and surgical procedures. Phlegmons of head and neck can drain into the spaces among the muscles, aponevrosis, organs inside the neck like sublingual space, lateral pharyngeal space, retro-pharyngeal space or pre-vertebral space. We hereby report our experience with 7 patients treated from 2001 to 2005.

Is a two-month healing period long enough to achieve osseointegration? A prospective clinical cohort study.

The aim of this study was to evaluate the effectiveness of loading at 2 months after the surgical placement of implants. A tapered implant was used. Implant stability was determined using resonance frequency analysis at implant insertion (T0; primary stability), after 2 months (T1), and at the 6-month follow-up (T2). Descriptive statistics and the t-test were used. Significance was at P ≤ 0.05. A total of 268 implants were inserted in 142 patients. No patient dropped out and no implant had failed at the 6-month follow-up. The mean implant stability quotient value (ISQ) increased over time, with a statistically non-significant difference for T0 vs. T1 (P = 0.08) and a statistically significant difference for T1 vs. T2 (P = 0.0018) and T0 vs. T2 (P = 0.000). Only 99 implants, characterized by an extremely high mean primary stability value (80.34), did not have a recorded increase in ISQ at T1. A 2-month healing period allowed the implant to achieve secondary stability, confirming the effectiveness of the loading protocol at 2 months.

Is there a learning curve in static computer-assisted implant surgery? A prospective clinical study.

Static computer-assisted surgery (s-CAS) has been introduced to improve the results of implantology. A prospective cohort study was conducted following the STROBE guidelines to determine the presence of a learning curve in s-CAS. Six partially and six totally edentulous patients were treated by two surgeons experienced in implantology but completely inexperienced in s-CAS. Preoperative and postoperative computed tomography scans were matched to assess coronal, apical, and angular deviation and the positioning error. The accuracy data were used to evaluate the learning curve. Fifty-six implants were inserted. In partially and totally edentulous patients, the mean (range; standard deviation) coronal deviation was 0.87 (0.34-1.27; 0.35) and 1.24 (0.72-2.67; 0.79); the mean apical deviation was 1.13 (0.48-1.63; 0.39) and 1.52 (0.88-3.84; 1.15); the mean angular deviation was 2.63 (1.89-4.50; 0.98) and 3.59 (1.69-6.30; 1.65); and the mean positioning error was 0.80 (0.32-1.25; 0.35) and 1.14 (0.35-2.56; 0.77), respectively. A typical 'learning curve' effect was not identified for s-CAS.

Are intraoral radiographs reliable in determining peri-implant marginal bone level changes? The correlation between open surgical measurements and peri-apical radiographs.

This study was performed to evaluate the reliability of peri-apical radiographs in determining peri-implant marginal bone level changes. The STROBE guidelines were followed. Marginal bone levels were measured at the time of implant insertion using a straight periodontal probe and using peri-apical radiographs. These intraoperative and radiographic measurements were repeated at the time of second surgery. All radiographs were analysed by two examiners blinded to the intraoperative measurements. To standardize the radiographic images, the long-cone parallel technique and a film-holding system were used. Intra-observer agreement and inter-observer variability were assessed using the intra-class correlation coefficient (ICC). Descriptive statistics, the t-test, and the Pearson correlation coefficient were also used. A total of 268 implants were inserted in 142 patients. Inter-observer agreement was 0.950; intra-observer variability was 0.980 and 0.973. The mean difference between the radiographic and intraoperative measurements was 0.50±1.55mm (range 0-8mm); the difference was statistically significant (P=0.000). A significant linear correlation was found between the marginal bone level changes evaluated intraoperatively and radiographically (P<0.005). Radiographic analysis significantly overestimated the level of peri-implant marginal bone compared to intraoperative measurements, but peri-apical radiographs are reliable in determining the bone level changes at different follow-ups.

Palatal orthodontic miniscrew insertion using a CAD-CAM surgical guide: description of a technique.

The aim of this report was to describe a new computer-guided technique for a controlled site preparation and palatal orthodontic miniscrew insertion using a dedicated software. A surgical guide was designed after planning the appropriate insertion sites on three-dimensional images created by the fusion of cone-beam computed tomography (CBCT) and digital dental model images. Pre- and postoperative CBCT images were compared and the angular, coronal, and apical deviations between the planned and the placed miniscrews were calculated. The mean coronal and apical deviations were 1.38mm (range: 3.48-0.15mm; standard deviation (SD): 0.65) and 1.73mm (range: 5.41-0.10mm; SD: 1.03), respectively, while the mean angular deviation was 4.60° (range: 15.23-0.54°; SD: 2.54). The present surgical guide allows a controlled and accurate palatal miniscrew placement in three dimensions.

How much does experience in guided implant surgery play a role in accuracy? A randomized controlled pilot study.

The current literature is not consistent on whether experience influences accuracy. The aim of this study was to analyze the accuracy of implant insertion performed by inexperienced versus experienced surgeons. Thirty-three implants were inserted by the inexperienced group and 37 implants by the experienced group. Planning and post-surgical computed tomography images were matched and the accuracy data compared. The positioning error was also evaluated. Quantitative data for the two groups were described and illustrated using box plots. The t-test was used to compare accuracy values and positioning error. Significance was set at P≤0.05. In the inexperienced group, the mean coronal, apical, and angular deviation values were 0.75mm (range 1.01-0.51, standard deviation (SD) 0.18), 1.02mm (range 1.99-0.64, SD 0.44), and 3.07° (range 9.22-0.73, SD 2.70). In the experienced group, the mean coronal, apical, and angular deviations were 0.60mm (range 1.00-0.06, SD 0.25), 0.67mm (range 1.67-0.24, SD 0.34), and 3.21° (range 8.01-1.41, SD 1.57). The t-test did not show any statistically significant difference when coronal (P=0.125), apical (P=0.060), and angular (P=0.859) deviations were considered. A statistically significant difference (P=0.000) was determined when the positioning error was considered. Experience had a limited influence on accuracy, but reduced positioning error to a statistically significant degree.

The accuracy of computer-guided piezocision: a prospective clinical pilot study.

Computer-guided piezocision can be used to overcome the disadvantages of corticotomy in accelerating orthodontic tooth movement. The aim of this clinical pilot study was to determine the accuracy of this technique. STROBE guidelines were followed. Ten patients were selected and treated. Using new dedicated planning software, the piezocision cuts were properly positioned in virtual models. A surgical guide was designed and printed with slots to guide the scalpel blade first and then the piezoelectric micro-saw. The slots limit the cortical incisions coronally and apically, and also limit the depth of penetration of the piezoelectric micro-saw. The patients underwent CBCT before and immediately after surgery, and the pre- and postoperative images were matched. Using software, the planned piezocisions were compared to the actual piezocisions, and the entry point and depth deviations were measured. Descriptive statistics, kappa statistics, and the t-test were used for the data analysis. The mean deviation at the entry point was 0.67mm (range 0.06-1.44mm, standard deviation 0.31). The mean depth deviation was 0.54mm (range 0.17-0.80mm, standard deviation 0.21). The limits of the use of computer-guided piezocision are set by the maximum deviation observed; thus a safety distance of 1.5mm should be considered, which confirms that this innovative technique is clinically applicable.

The influence of mandibular third molar germectomy on the treatment time of impacted mandibular second molars using brass wire: a prospective clinical pilot study.

The brass wire ligature is an efficient method to correct a moderately mesially impacted mandibular second molar (MM2). The aim of this prospective clinical pilot study was to evaluate the influence of mandibular third molar (MM3) germectomy on the treatment time for this procedure and to determine its impact on oral health-related quality of life (OHRQoL) using the short-form Oral Health Impact Profile (OHIP-14). The STROBE guidelines were followed. Impacted MM2 were assigned randomly to receive brass wire ligature treatment either with germectomy (group A) or without germectomy (group B). Descriptive statistics and the Student t-test were used in the statistical analysis; significance was set at P≤0.05. One thousand and thirty patients were assessed. Fourteen subjects with 20 mesially angulated (range 25-40°) impacted MM2 were identified. Paired comparisons of groups A and B showed no statistically significant difference in treatment time (171days for group A and 174days for group B; P=0.440), but a statistically significant difference in OHIP-14 values at the 3- (P=0.017) and 7-day (P=0.002) follow-up. The brass wire technique can be used effectively in moderately impacted MM2, but the combined use of MM3 germectomy does not influence the treatment time and shows a negative impact on OHRQoL.

Immediate loading of implants inserted in edentulous arches using multiple mucosa-supported stereolithographic surgical templates: a 10-year prospective cohort study.

The purpose of this prospective study was to evaluate survival and marginal bone loss at 10-year follow-up of implants inserted in completely edentulous arches and immediately loaded using multiple mucosa-supported stereolithographic surgical templates. The influence on marginal bone loss of the following variables was evaluated: sex, smoking habit, arch, implant position, implant diameter, and implant length. Prosthesis survival and success were also determined. STROBE guidelines were followed. One hundred and eighty-eight implants were inserted in 16 consecutively selected patients using a prefabricated metal-reinforced full-arch provisional acrylic restoration. The definitive metal-ceramic full-arch prosthesis was delivered within 2 weeks. Kappa statistics, two-way analysis of variance (ANOVA) with Bonferroni adjusted post hoc test, one-way ANOVA with Tukey's range test, and unpaired Student t-tests were used for the analysis. Four implants failed during the first year of function (maxilla 3, mandible 1), leading to a 10-year survival rate of 97.9%. The mean marginal bone loss after 10 years was 0.76 mm. The marginal bone changes were found not to be influenced significantly by the variables evaluated (P > 0.05). The prosthetic success rate was 66.7%; no prosthesis failures occurred. In conclusion the technique described is a predictable treatment option with high survival in the long-term follow-up.

Peri-implant bone loss around platform-switched Morse taper connection implants: a prospective 60-month follow-up study.

The aim of this study was to measure the crestal bone level changes at 60 months of follow-up and to evaluate the influence of biologically relevant, anatomical, and implant-related variables. A prospective study design was used. STROBE guidelines were followed. A total of 576 implants were inserted in 270 patients needing an implant-supported, partial, fixed dental prosthesis or a single crown. Standardized peri-apical radiographs were obtained at 2 months (time of implant-abutment connection and prosthetic loading) and 60 months of follow-up. Descriptive statistics were used and inter- and intra-examiner reliability determined. A mixed model was used to evaluate the predictor variables. The correlation among multiple implants inserted in a single patient was considered. Significance was assessed using the type 3 test. Sensitivity analyses, least-squares means analyses, t-tests, and χ2 tests were also conducted. The statistical analysis was performed at the implant level; P<0.05 indicated statistical significance. At the 60-month follow-up, the mean marginal bone remodelling was -0.59±1.34mm (range -5.70 to 3.65mm). Marginal bone loss was significantly influenced by implant depth, implant location, and the interactions implant depth×jaw, implant location×timing of implant placement, and jaw×implant diameter. At the 60-month follow-up, a low mean marginal bone loss was found, which was significantly higher with subcrestal implants and anterior implants.

Minimally invasive corticotomy in orthodontics using a three-dimensional printed CAD/CAM surgical guide.

The aim of this prospective study was to evaluate the effectiveness of an innovative, minimally invasive, flapless corticotomy procedure in orthodontics. The STROBE guidelines were followed. Ten patients with severe dental crowding and a class I molar relationship were selected to receive orthodontic treatment with clear aligners and corticotomy-facilitated orthodontics. The mean age of these patients was 21 years (range 17-28, standard deviation 6.08 years); the male to female ratio was 2:1. The main outcome was a reduction in the total treatment time to correct dental crowding. The secondary outcomes were periodontal index changes, the degree of root resorption, and patient perceptions of the method used, assessed using the short-form Oral Health Impact Profile (OHIP-14). The occurrence of early surgical complications or unexpected events was also recorded. All patients completed the treatment to correct dental crowding. The average treatment time was reduced by two-thirds. The procedure did not significantly modify the periodontal indices or oral health-related quality of life. No early surgical complications or unexpected events were observed. In short, the results indicate that this new procedure is safe and accelerates tooth movement without periodontal complications or discomfort. However, the efficacy of this procedure must be confirmed in controlled clinical trials.

Minimally invasive corticotomy in orthodontics: a new technique using a CAD/CAM surgical template.

Accelerating orthodontic tooth movement is a topical issue. Despite the different techniques described in the literature, the corticotomy is the only effective and safe means of accelerating orthodontic tooth movement. Although effective, the corticotomy presents significant postoperative discomfort. The aggressive nature of these particular methods, related to the elevation of mucoperiosteal flaps and to the length of the surgery, has resulted in reluctance to proceed with this technique among both patients and the dental community. To overcome the disadvantages of the corticotomy, this technical note describes an innovative, minimally invasive, flapless procedure combining piezoelectric surgical cortical micro-incisions with the use of a 3D Printed CAD/CAM surgical guide.