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INTRODUCTION: This study aimed to compare the effect of two preservative-free (PF) artificial tears, one containing carboxymethylcellulose (CMC) (control group) vs another containing hyaluronic acid and hydroxypropyl guar (HA + HP-guar) (study group), on the healing of the corneal epithelium and the ocular discomfort after bilateral photorefractive keratectomy (PRK) surgery. METHODS: A total of 68 patients that were scheduled to have PRK to correct myopia were randomized into two groups: 34 patients (68 eyes) in the study group and 34 patients (68 eyes) in the control group. Ocular examinations were performed on postoperative days 1, 4, 7, 30, and 90, evaluating the diameter of the de-epithelized cornea, the fluorescein staining using the Oxford scale, the tear film osmolarity and stability (tear breakup time), and the pain using visual analog scale (VAS). RESULTS: On postoperative day 4, 97% of the study eyes vs 84.4% of the control eyes were completely re-epithelized (p = 0.01). Less ocular pain was observed on postoperative day 3 in the study group (5.0 (3.0-6.0) vs 6.0 (3.5-7.0), p = 0.03). No differences were observed beyond postoperative day 7 in the healing of the corneal epithelium, non-invasive Keratograph breakup time (NIKBUT), and the self-perceived ocular discomfort between the two groups. CONCLUSION: The current study shows faster healing of the corneal epithelium and less ocular pain and discomfort in the first days after PRK with the use of topical lubricants containing HA + HP-guar compared to conventional CMC artificial tears, probably due to the different trophic effect of the aforementioned tears on the corneal epithelial cells. TRIAL REGISTRATION: EudraCT No. 2020-003488-25.
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Se realizó un estudio descriptivo y transversal de 23 pacientes VIH/SIDA hospitalizados en el sanatorio "El Caguayo" del municipio de San Luis, Santiago de Cuba, en el primer semestre de 1997, con el objetivo de hacer un pesquisaje de tuberculosis pulmonar. Las edades más afectadas oscilaron entre 15 y 34 años, con predominio del sexo masculino. Los síntomas más frecuentes fueron: tos, expectoración y febrícula. No se diagnosticó ningún caso con la afección antes mencionada, pero no obstante se aplicó tratamiento quimioprofiláctico con isoniacida al total de la muestra(AU)
A cross-sectional and descriptive study of 23 HIV/AIDS patients hospitalized in «El Caguayo¼ sanatorium, in the municipality of San Luis, Santiago de Cuba, during the first semester of 1997, was conducted aimed at making a screening of pulmonary tuberculosis. The most affected ages ranged between l5 and 34, with predominance of the male sex. The most frequent symptoms were: cough, expectoration and febricula. No case with the afore mentioned affection was diagnosed; however, chemoprophylactic treatment with isionazide was applied to the whole sample(AU)
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Humanos , Masculino , Adolescente , Adulto , Tuberculose Pulmonar/tratamento farmacológico , Tuberculose Pulmonar/epidemiologia , Síndrome da Imunodeficiência Adquirida/enfermagem , Síndrome da Imunodeficiência Adquirida/epidemiologia , Mycobacterium tuberculosis/patogenicidade , Epidemiologia Descritiva , Estudos TransversaisRESUMO
Se mencionan los signos clínicos y de laboratorio que algunos autores toman en consideración para calificar al recién nacido como sano, posiblemente séptico o séptico, se enumeran los pasos necesarios de toma de muesstras para cultivos útiles al sospechar bacteremia, por ejemplo, antes manifestaciones clínicas de sépsis neonatal, ruptura prematura de membranas (más de 12 horas), colonización materna por Streptococcus beta hemolítico grupo B e infección ocular del neonatato por Chlamydia trachomatis. Finalmente se discute la importancia de reconocer la etiología de la infección comunitaria u hospitalaria
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Recém-Nascido , Humanos , Infecções Bacterianas/diagnóstico , Recém-Nascido , Sepse/diagnóstico , Sepse/prevenção & controle , Infecções/diagnóstico , Microbiologia , NeonatologiaRESUMO
La sepsis neonatal puede ocurrir en 14 por ciento nacidos vivos, debiendo sospecharse ante la presencia de sufrimiento fetal a causa no conocida, letargia, hipotomía, irritabilidad anormal, inestabilidad térmica, dificultad respiratoria, ictericia de curso anormal y progreso inadecuado. El siguiente articulo tiene por finalidad discernir sobre el valor diagnóstico de los diferentes índices clínicos en comparación con el aislamiento microbiológico por cultivo